Biomarker: NF-YAs

Histology type: endometrial carcinoma

Stage: low grade

Country: Italy

Region: Rome

Study type: retrospective study

Followed up time :

Subgroup 1 name : G1 EECs

Subgroup 1 number: 29

Subgroup 2 name: G2-G3 EECs

Subgroup 2 number: 49

Conclusion: We identified NF-YAs expression levels as novel potential biomarkers useful to identify G1 ECs patients with risk of recurrence.

Sample type : tissue

Sample method: quantitative PCR / western blotting /immunoblotting

Expression pattern : expression

Statictics: Mean ;Range

Cohort age: 63;42-88

Subgroup 1 age: 58;42-76

Subgroup 2 age: 66;43-88

Funtion Uniprot: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

UniProt ID: P23511

UniProt Link: https://www.uniprot.org/uniprotkb/P23511/entry

Biological function from UniProt: Biological rhythms, Transcription, Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Nuclear transcription factor Y subunit alpha

Gene name from HGNC: NFYA (CBF-B, HAP2, NF-YA)

HPA class: Transcription factors

AlphaFold DB: P23511

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P23511

HPA link: https://www.proteinatlas.org/ENSG00000001167-NFYA

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General nuclear expression, high in leukocytes.

Single cell type specificity Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000001167-NFYA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000001167-NFYA/pathology/endometrial+cancer

Expression figure legend: Analysis of NF-YA isoforms and lamin A protein expression in benign and EC tissues

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352372/figure/F1/?report=objectonly

OMIM: 189903

OMIM link2: https://www.omim.org/entry/189903

HGNC ID: HGNC:7804

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7804