Biomarker: ZIC2

Histology type: endometrial carcinoma

Country: China

Followed up time :

Conclusion: In conclusion, the findings of the present study indicated that ZIC2 may upregulate SNHG12 expression to promote EC cell proliferation and migration by activating the Notch signaling pathway.

Funtion description: ZIC2 knockdown inhibited RL95‑2 cell proliferation, migration and invasion. The protein expression levels of Ki67, proliferating cell nuclear antigen, MMP2 and MMP9 were also downregulated following the knockdown of ZIC2.ZIC2 was predicted to bind to SNHG12 and positively regulate SNHG12 expression.ZIC2 knockdown inhibited Notch signaling activation, while SNHG12 overexpression reversed this effect.

Funtion Uniprot: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

UniProt ID: O95409

UniProt Link: https://www.uniprot.org/uniprotkb/O95409/entry

Biological function from UniProt: #Differentiation #Neurogenesis #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: Zinc finger protein ZIC 2

Gene name from HGNC: ZIC2 (HPE5)

HPA class: Disease related genes Human disease related genes Plasma proteins Transcription factors

AlphaFold DB: O95409

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O95409

HPA link: https://www.proteinatlas.org/ENSG00000043355-ZIC2

Tissue specificity RNA from HPA: Group enriched (brain, choroid plexus)

Tissue expression from HPA: Disease related genes Human disease related genes Plasma proteins Transcription factors

Single cell type specificity Cell type enhanced (Microglial cells, Astrocytes, Muller glia cells, Cone photoreceptor cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nuclear bodies

Cancer prognostic summary HPA Prognostic marker in cervical cancer (favorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000043355-ZIC2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000043355-ZIC2/pathology/endometrial+cancer

Phenotype ID: 609637

Disease: Holoprosencephaly 5 (HPE5)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 603073

OMIM link1: https://www.omim.org/entry/609637

OMIM link2: https://www.omim.org/entry/603073

HGNC ID: HGNC:12873

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12873