Biomarker: SHP-1

Histology type: endometrial serous carcinomas

Stage: high grade

Country: Italy

Region: Piacenza

Study type: retrospective study

Followed up time :

Subgroup 1 name : Positive

Subgroup 1 number: 105

Subgroup 2 name: Negative

Subgroup 2 number: 23

Conclusion: In this study, we observed that the absence of SHP-1 in immunohistochemical analysis might serve as a marker of poor prognosis for a subset of high-grade endometrial cancer.

Sample type : tissue

Sample method: Immunohistochemistry

Expression pattern : absence of SHP-1

Funtion Uniprot: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

UniProt ID: P29350

UniProt Link: https://www.uniprot.org/uniprotkb/P29350/entry#function

Molecular function from UniProt:

Tissue specificity from UniProt: Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Catalytic activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate

Recommended name: Tyrosine-protein phosphatase non-receptor type 6

Gene name from HGNC: PTPN6 (HCP, HCPH, PTP-1C, SHP-1, SHP1)

HPA class: Enzymes Metabolic proteins Plasma proteins

AlphaFold DB: P29350

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P29350

HPA link: https://www.proteinatlas.org/ENSG00000111679-PTPN6

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, lymphoid tissue)

Tissue expression from HPA: Distinct cytoplasmic expression in immune tissues.

Single cell type specificity Cell type enhanced (B-cells, Hofbauer cells, NK-cells, Macrophages, Kupffer cells, granulocytes, Langerhans cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli

Cancer prognostic summary HPA Prognostic marker in urothelial cancer (favorable), cervical cancer (favorable), colorectal cancer (unfavorable) and endometrial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000111679-PTPN6/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000111679-PTPN6/tissue/endometrium

OMIM: 176883

OMIM link2: https://www.omim.org/entry/176883

HGNC ID: HGNC:9658

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9658