Biomarker: GABPA

Histology type: endometrial carcinoma

Country: China

Region: Shandong

Study type: retrospective Study

Followed up time :

Subgroup 1 name : High expression in EC Patients

Subgroup 1 number: 43

Subgroup 2 name: Low expression EC Patients

Subgroup 2 number: 64

Conclusion: GABPA may act as an independent predictor of clinical prognosis;serve as a potential target gene for EC therapy.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : downregulated

Statictics: Mean (SD)

Cohort age: 55.16 ± 9.74

Funtion description: To determine whether the methylation of GABPA results in its suppression, we analyzed the relationship between the gene methylation level and mRNA expression of GABPA in ECs using TCGA. The results demonstrate that GABPA mRNA expression is negatively correlated with its gene methylation level (R = −0.2512, P < 0.001). Moreover, we identified one methylated CpG at cg21890848 of GABPA gene played a predominant role in its silence (R = −0.2506, P < 0.001) (Figure 7(b)). Above results indicated that aberrant methylation is one of the major mechanisms for the silencing of the GABPA gene.

Funtion Uniprot: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

UniProt ID: Q06546

UniProt Link: https://www.uniprot.org/uniprotkb/Q06546/entry#f

Biological function from UniProt: Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Low tissue specificity

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: GA-binding protein alpha chain

Gene name from HGNC: GABPA (E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A)

HPA class: Transcription factors

AlphaFold DB: Q06546

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q06546

HPA link: https://www.proteinatlas.org/ENSG00000154727-GABPA

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear expression in most cell types.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000154727-GABPA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000154727-GABPA/pathology/endometrial+cancer

Expression figure legend: The association of GABPA mRNA and its gene methylation was analyzed by TCGA database

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263239/figure/fig7/

OMIM: 600609

OMIM link2: https://www.omim.org/entry/600609

HGNC ID: HGNC:4071

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4071