Basic information
Biomarker: SerpinE2
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Guangzhou
Followed up time :
Subgroup 1 name : LMS
Subgroup 1 number: 171
Subgroup 2 name: LG-ESS
Subgroup 2 number: 74
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 72 | EC | 72 |
Sample information
Conclusion: SerpinE2, a poor biomarker of endometrial cancer, promotes the proliferation and mobility of EC cells
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Expression elevation: The dominant staining intensity in tumor cells was scored as 0 = negative; 1 = weak (0 ∼ 25%); 2 = intermediate (26 ∼ 50%); 3 = strong (51 ∼ 75%); or 4 = extra strong (76 ∼ 100%). We calculated the dominant staining in80 tensity from five views and added the scores together.
Disease information
Statictics: Median;Range
Cohort age: 57;20-90
Related information
Funtion description: Knocked down SerpinE2 by siRNA in the HTB-111 and Ishikawa EC cell lines and analyzed the viability and mobility change using an MTT assay, an annexin V/PI apoptosis assay, a wound scratch test and a transwell assay. Silencing SerpinE2 induced cell apoptosis and reduced the migration ability.
Funtion Uniprot: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
UniProt ID: P07093
UniProt Link: https://www.uniprot.org/uniprotkb/P07093/entry
Biological function from UniProt: Differentiation, Neurogenesis
Molecular function from UniProt:
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Gene name from HGNC: SERPINE2 (GDN, nexin, PI7, PN1, PNI)
HPA class: Plasma proteins
HPA link: https://www.proteinatlas.org/ENSG00000135919-SERPINE2
Tissue specificity RNA from HPA: Tissue enriched (placenta)
Single cell type specificity Cell type enriched (Granulosa cells)
Immune cell specificity: Group enriched (NK-cell, naive CD4 T-cell, naive CD8 T-cell)
Subcellular summary HPA Located in Golgi apparatus
Cancer prognostic summary HPA Prognostic marker in urothelial cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000135919-SERPINE2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000135919-SERPINE2/pathology/endometrial+cancer
OMIM: 177010
OMIM link2: https://www.omim.org/entry/177010
HGNC ID: HGNC:8951
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8951
