Biomarker: YKL-40

Histology type: endometrial carcinoma

Stage: early stage

Country: Poland

Region: Warsaw

Study type: single institution study

Followed up time :

Subgroup 1 name : LMS

Subgroup 1 number: 171

Subgroup 2 name: LG-ESS

Subgroup 2 number: 74

Conclusion: A high diagnostic sensitivity of YKL-40 in the early stages of the disease suggests the possibility of using this biomarker at an early diagnostic phase of patients with EC.

Sample type : serum

Sample method: ELISA

Expression pattern : preoperative higher serum level(cutoff=55.4 ng/mL)

Statictics: Median;Range

Cohort age: 57;20-90

Funtion Uniprot: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

UniProt ID: P36222

UniProt Link: https://www.uniprot.org/uniprotkb/P36222/entry

Biological function from UniProt: Apoptosis, Inflammatory response

Molecular function from UniProt:

Tissue specificity from UniProt: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

Subcellular UniProt: #Cytoplasm #Endoplasmic reticulum #Secreted

Alternative name from UniProt:

Gene name from HGNC: CHI3L1 (GP39, YK-40, YKL40)

Induction: Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.

HPA link: https://www.proteinatlas.org/ENSG00000133048-CHI3L1

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, brain, liver)

Subcellular summary HPA Located in Golgi apparatus, Vesicles

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000133048-CHI3L1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000133048-CHI3L1/pathology/endometrial+cancer

Disease: Asthma-related traits 7 (ASRT7);Schizophrenia (SCZD)

Note1: Disease susceptibility is associated with variants affecting the gene represented in this entry;Disease susceptibility is associated with variants affecting the gene represented in this entry;

Note2: Disease susceptibility is associated with variants affecting the gene represented in this entry;Disease susceptibility is associated with variants affecting the gene represented in this entry;

OMIM: 611960;181500;601525

OMIM link1: https://www.omim.org/entry/611960;https://www.omim.org/entry/181500;

OMIM link2: https://www.omim.org/entry/611960;https://www.omim.org/entry/181500;

Phenotype: Asthma-related traits 7 (ASRT7);Schizophrenia (SCZD)

HGNC ID: HGNC:1932

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1932