Basic information
Biomarker: CCND2
Histology type: endometrial stromal tumor
Cohort characteristics
Country: Norway
Region: Oslo
Study type: retrospective study
Followed up time :
Subgroup 1 name : LMS
Subgroup 1 number: 171
Subgroup 2 name: LG-ESS
Subgroup 2 number: 74
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 305 | LMS | 231 | LG-ESS | 74 |
Sample information
Conclusion: CCND2 are novel candidate prognostic markers in uterine leiomyosarcoma .
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : nuclear expression
Expression elevation: IHC scoring: Staining extent and intensity were scored separately by two surgical pathologists (BK and BD). Tumors were scored as negative (0% stained cells), focally positive (1–10% stained cells), moderately positive (11–50% stained cells), or diffusely positive (staining in >50% cells),corresponding to a score of 0–3.
Disease information
Statictics: Median;Range
Cohort age: 57;20-90
Related information
Funtion Uniprot: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition (PubMed:8114739, PubMed:18827403). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase (PubMed:8114739, PubMed:18827403). Hypophosphorylates RB1 in early G1 phase (PubMed:8114739, PubMed:18827403). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403).
UniProt ID: P30279
UniProt Link: https://www.uniprot.org/uniprotkb/P30279/entry
Biological function from UniProt: Cell cycle, Cell division
Molecular function from UniProt:
Subcellular UniProt: #Cytoplasm #Membrane #Nucleus
Gene name from HGNC: CCND2
HPA link: https://www.proteinatlas.org/ENSG00000118971-CCND2
Tissue specificity RNA from HPA: Low tissue specificity
Tissue expression from HPA: Cytoplasmic and nuclear expression in several tissues.
Subcellular summary HPA Located in Nucleoplasm (Single cell variability, CCD Protein, CCD Transcript)
Cancer prognostic summary HPA Prognostic marker in thyroid cancer (favorable) and pancreatic cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000118971-CCND2/tissue
Pathology endo: https://www.proteinatlas.org/ENSG00000118971-CCND2/tissue/duodenum
HGNC ID: HGNC:1583
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1583
