Basic information
Biomarker: NAV2
Histology type: endometrial stromal tumor
Stage: low grade
Cohort characteristics
Country: Norway
Region: Oslo
Study type: retrospective study
Followed up time :
Subgroup 1 name : LMS
Subgroup 1 number: 171
Subgroup 2 name: LG-ESS
Subgroup 2 number: 74
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 305 | uterine leiomyosarcoma | 231 | low-grade endometrial stromal sarcomas | 74 |
Sample information
Conclusion: NAV2 are novel candidate prognostic markers in LG-ESS.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Expression elevation: IHC scoring: Staining extent and intensity were scored separately by two surgical pathologists (BK and BD). Tumors were scored as negative (0% stained cells), focally positive (1–10% stained cells), moderately positive (11–50% stained cells), or diffusely positive (staining in >50% cells),corresponding to a score of 0–3.
Disease information
Statictics: Median;Range
Cohort age: 57;20-90
Related information
Funtion Uniprot: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.
UniProt ID: Q8IVL1
UniProt Link: https://www.uniprot.org/uniprotkb/Q8IVL1/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.
Subcellular UniProt: #Nucleus
Alternative name from UniProt:
Catalytic activity: ATP + H2O = ADP + H+ + phosphate
Gene name from HGNC: NAV2 (FLJ10633, FLJ11030, FLJ23707, HELAD1, KIAA1419, POMFIL2, RAINB1)
Induction: By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.
HPA link: https://www.proteinatlas.org/ENSG00000166833-NAV2
Tissue specificity RNA from HPA: Tissue enhanced (brain, heart muscle)
Tissue expression from HPA: Cytoplasmic expression at variable levels in most tissues.
Subcellular summary HPA Located in Nucleoplasm
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000166833-NAV2/tissue
Pathology endo: https://www.proteinatlas.org/ENSG00000166833-NAV2/tissue/duodenum
OMIM: 607026
OMIM link2: https://www.omim.org/entry/607026#title
HGNC ID: HGNC:15997
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15997
