Basic information
Biomarker: GalNAc-T6
Histology type: endometrial carcinoma
Stage: high grade
Cohort characteristics
Country: Janpanese
Region: Kitakyushu
Study type: retrospective study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 218 | endometrial carcinomas | 218 |
Sample information
Conclusion: Positive expression of GalNAc-T6 was significantly associated with better histological grade;good clinical prognosis of patients
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Disease information
Related information
Funtion Uniprot: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.
UniProt ID: Q8NCL4
UniProt Link: https://www.uniprot.org/uniprotkb/Q8NCL4/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow.
Subcellular UniProt: #Golgi apparatus #Membrane
Alternative name from UniProt:
Catalytic activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP
Gene name from HGNC: GALNT6 (GalNAc-T6)
HPA link: https://www.proteinatlas.org/ENSG00000139629-GALNT6
Tissue specificity RNA from HPA: Tissue enhanced (stomach)
Tissue expression from HPA: Cytoplasmic expression with a granular pattern, mainly in glandular cells of the intestinal tract and epididymis.
Subcellular summary HPA Located in Nucleoplasm, Golgi apparatus;
Cancer prognostic summary HPA Prognostic marker in ovarian cancer (favorable) and endometrial cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000139629-GALNT6/tissue
Pathology endo: https://www.proteinatlas.org/ENSG00000139629-GALNT6/tissue/duodenum
OMIM: 605148
OMIM link2: https://www.omim.org/entry/605148
HGNC ID: HGNC:4128
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4128
