Biomarker: GABPA

Histology type: endometrial carcinoma

Country: China

Region: Shandong

Study type: retrospective Study

Followed up time :

Subgroup 1 name : High expression in EC Patients

Subgroup 1 number: 43

Subgroup 2 name: Low expression EC Patients

Subgroup 2 number: 64

Conclusion: GABPA may act as an independent predictor of clinical prognosis;serve as a potential target gene for EC therapy.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : low expression( score < 6)

Expression elevation: The expression of GABPA was assessed according to the immunoreactive score (IRS), determined by evaluating the proportion of positive tumor cells, scored as 0 (≤5% positive tumor cells), 1 (6-25% positive tumor cells), 2 (26-50% positive tumor cells), 3 (51-75% positive tumor cells), and 4 (≥76% positive tumor cells) and the intensity of their staining, graded as 0 (negative), 1 (weak), 2 (moderate), and 3 (strong). The staining intensity score was then multiplied by the proportion of positive cells to obtain the immunoreactive score for each sample, ranging from 0 to 12. In order to facilitate statistical evaluation, the GABPA protein expression level was reclassified according to semiquantitative scheme. Low levels of expression were defined as immunoreactive score < 6, and high levels of expression were defined as immunoreactive score ≥ 6.

Statictics: Mean (SD)

Cohort age: 55.16 ± 9.74

Funtion Uniprot: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

UniProt ID: Q06546

UniProt Link: https://www.uniprot.org/uniprotkb/Q06546/entry#f

Biological function from UniProt: Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Low tissue specificity

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: GA-binding protein alpha chain

Gene name from HGNC: GABPA (E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A)

HPA class: Transcription factors

AlphaFold DB: Q06546

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q06546

HPA link: https://www.proteinatlas.org/ENSG00000154727-GABPA

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear expression in most cell types.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000154727-GABPA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000154727-GABPA/pathology/endometrial+cancer

Expression figure legend: The expression of GABPA in EC patients was analyzed by IHC

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263239/figure/fig5/

Survival figure legend: Kaplan-Meier survival analysis of the GABPA expression in EC patients by the TCGA database$ Subgroup analyses of the GABPA expression in EC patients by the TCGA database$ Kaplan-Meier survival analysis of the GABPA expression in EC patients by IHC

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263239/figure/fig2/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263239/figure/fig3/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263239/figure/fig6/$

OMIM: 600609

OMIM link2: https://www.omim.org/entry/600609

HGNC ID: HGNC:4071

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4071