Biomarker: NTSR1

Histology type: endometrial carcinoma

Country: France

Region: CHRU de Nancy，Lorraine

Study type: retrospective study

Followed up time :

Conclusion: NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS in endometrial cancer progression and its uses as a prognostic marker, and as a potential therapeutic target.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Cytoplasmic staining for NTSR1 was evaluated using a semi-quantitative score. The staining intensity was graded as follows: 1, weak; 2, medium; and 3, strong. A score was obtained by multiplying the percentage of positive cells by the intensity level (range: 0–300).

Statictics: Mean (SD)

Cohort age: 67.58 ± 11.26

Funtion Uniprot: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi

UniProt ID: Q99523

UniProt Link: https://www.uniprot.org/uniprotkb/Q99523/entry

Biological function from UniProt: #Differentiation #Endocytosis #Osteogenesis #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.

Subcellular UniProt: #Cell membrane #Endoplasmic reticulum #Endosome #Golgi apparatus #Lysosome

Alternative name from UniProt:

Gene name from HGNC: NTSR1 (NTR)

Induction: During osteoblast differentiation

HPA link: https://www.proteinatlas.org/ENSG00000101188-NTSR1

Tissue specificity RNA from HPA: Group enriched (brain, intestine)

Subcellular summary HPA Located in Plasma membrane

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000101188-NTSR1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000101188-NTSR1/pathology/endometrial+cancer

OMIM: 602458;613589;

OMIM link2: https://www.omim.org/entry/602458;https://www.omim.org/entry/613589;

Phenotype: LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6; LDLCQ6

HGNC ID: HGNC:8039

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8039