Biomarker: SUSD2

Histology type: endometrial carcinoma

Followed up time :

Conclusion: These findings suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer.

Funtion description: SUSD2 is present in endometrial carcinoma cells. Ssuppression of SUSD2 expression following treatment with TGFβ or by siRNA increased apoptosis and senescence

Funtion Uniprot: May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994)

UniProt ID: Q9UGT4

UniProt Link: https://www.uniprot.org/uniprotkb?query=SUSD2

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403).

Subcellular UniProt: #Cell membrane #Membrane

Gene name from HGNC: SUSD2 (BK65A6.2, FLJ22778, W5C5)

HPA link: https://www.proteinatlas.org/ENSG00000099994-SUSD2

Tissue specificity RNA from HPA: Tissue enhanced (lung)

Tissue expression from HPA: General cytoplasmic and membranous expression, most abundant in lung and kidney.

Subcellular summary HPA Located in Plasma membrane

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000099994-SUSD2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000099994-SUSD2/pathology/endometrial+cancer

OMIM: 615825

OMIM link2: https://www.omim.org/entry/615825

HGNC ID: HGNC:30667

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30667