Biomarker: HER2

Histology type: endometrial carcinoma

Country: Norway

Region: Hordaland County

Followed up time :

Subgroup 1 name : low expression

Subgroup 1 number: 656

Subgroup 2 name: high expression

Subgroup 2 number: 134

Conclusion: Loss of HER2 expression is common in metastatic endometrial cancer lesions and assessment of HER2 levels in the metastatic lesions may be important to define the potential benefit of anti-HER2 treatments in endometrial cancer patients.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression(3+)

Expression elevation: Staining intensity was classified from 0 (no staining) to 3 (strong staining). Quantity of stained tumour cells was classified as 0, 1 (<10%), 2 (10 to 50%) and 3 (>50%).The HercepTest Score using two categories (3+ vs <3+) and good (kappa value=0.74) using four categories. HercepTest Score 2+ was defined as moderate and 3+ as high HER2 expression.

Statictics: Mean

Subgroup 1 age: 65

Subgroup 2 age: 70

Funtion Uniprot: Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

UniProt ID: Q8TCG1

UniProt Link: https://www.uniprot.org/uniprotkb/Q8TCG1/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).

Subcellular UniProt: #Cytoplasm #Membrane

Alternative name from UniProt:

Miscellaneous: Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.

Gene name from HGNC: CIP2A (KIAA1524)

HPA link: https://www.proteinatlas.org/ENSG00000163507-CIP2A

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, lymphoid tissue)

Tissue expression from HPA: Cytoplasmic and membranous expression in most tissues.

Subcellular summary HPA Located in Plasma membrane, Cytosol (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable), renal cancer (unfavorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000163507-CIP2A/tissue

Survival figure legend: Relationship between HER2 expression (assessed by the HercepTest) and survival, mRNA expression and aggressiveness of disease$ Disease-specific survival (DSS) according to the staining index (SI) criteria and apical HER2 loss

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808034/figure/fig1/$ Disease-specific survival (DSS) according to the staining index (SI) criteria and apical HER2 loss.

OMIM: 610643

OMIM link2: https://www.omim.org/entry/610643

HGNC ID: HGNC:29302

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29302