Biomarker: mPRγ

Histology type: endometrial carcinoma

Region: Slovenia

Followed up time :

Conclusion: Membrane progesterone receptors γ has potential as prognostic biomarkers of endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Both intensity and percentage of stained cells were evaluated semiquantitatively. Staining intensity was evaluated as no staining (0), weak staining (1), moderate staining (2), and strong staining (3). The percentage of positive cells in sample was evaluated from 0 to 100%. The immunohistochemical scores (Q) were calculated by multiplying the percentages of positive cells (P) by the average intensities (I) (i.e.,Q = P × I; maximum score, 300).

Statictics: Mean (SD)

Cohort age: 62.5 ± 13.6

Funtion Uniprot: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).

UniProt ID: Q6TCH4

UniProt Link: https://www.uniprot.org/uniprotkb/Q6TCH4/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Brain specific (PubMed:16044242, PubMed:23763432). Highly expressed in the hypothalamus, also expressed in forebrain, amygdala, corpus callosum and spinal cord (PubMed:23161870).

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Miscellaneous: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

Recommended name: Membrane progestin receptor delta

Gene name from HGNC: PAQR6 (FLJ22672, PRdelta)

AlphaFold DB: Q6TCH4

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q6TCH4

HPA link: https://www.proteinatlas.org/ENSG00000160781-PAQR6

Tissue specificity RNA from HPA: Group enriched (brain, choroid plexus)

Single cell type specificity Group enriched (Muller glia cells, Oligodendrocytes, Astrocytes)

Immune cell specificity: Immune cell enriched (NK-cell)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), colorectal cancer (unfavorable), urothelial cancer (favorable) and prostate cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000160781-PAQR6/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000160781-PAQR6/pathology/endometrial+cancer

OMIM: 614579

OMIM link2: https://www.omim.org/entry/614579

HGNC ID: HGNC:30132

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30132