Biomarker: mPRβ

Histology type: endometrial carcinoma

Region: Slovenia

Followed up time :

Conclusion: Membrane progesterone receptors β has potential as prognostic biomarkers of endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Both intensity and percentage of stained cells were evaluated semiquantitatively. Staining intensity was evaluated as no staining (0), weak staining (1), moderate staining (2), and strong staining (3). The percentage of positive cells in sample was evaluated from 0 to 100%. The immunohistochemical scores (Q) were calculated by multiplying the percentages of positive cells (P) by the average intensities (I) (i.e.,Q = P × I; maximum score, 300).

Statictics: Mean (SD)

Cohort age: 62.5 ± 13.6

Funtion Uniprot: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870)

UniProt ID: Q8TEZ7

UniProt Link: https://www.uniprot.org/uniprotkb/Q8TEZ7/entry

Biological function from UniProt: #Differentiation #Oogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Miscellaneous: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).

Recommended name: Membrane progestin receptor beta

Gene name from HGNC: PAQR8 (C6orf33, LMPB1, MPRB)

HPA class: Transporters

AlphaFold DB: Q8TEZ7

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q8TEZ7

HPA link: https://www.proteinatlas.org/ENSG00000170915-PAQR8

Tissue specificity RNA from HPA: Tissue enhanced (brain)

Single cell type specificity Cell type enhanced (Oligodendrocytes, Astrocytes, Distal enterocytes, Proximal enterocytes, Paneth cells, Microglial cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Golgi apparatus, Plasma membrane

Cancer prognostic summary HPA Prognostic marker in breast cancer (favorable) and urothelial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000170915-PAQR8/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000170915-PAQR8/pathology/endometrial+cancer

OMIM: 607780

OMIM link2: https://www.omim.org/entry/607780

HGNC ID: HGNC:15708

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15708