Biomarker: HE4

Histology type: endometrial carcinoma

Region: Nijmegen

Study type: retrospective study.

Followed up time :

Subgroup 1 name : elevated serum levels in recurrance

Subgroup 1 number: 18

Subgroup 2 name: not elevated serum levels in recurrance

Subgroup 2 number: 6

Conclusion: Elevated serum HE4 is an independent risk factor for reduced disease-free survival and overall survival. HE4 seems to be superior to CA125 in the detection of recurrent disease during follow-up, mainly in high-risk endometrial cancer patients who are more prone to distant metastasis.

Sample type : serum

Sample method: ELISA

Expression pattern : elevated serum HE4(cut-off value 70 pmol/L)

Funtion Uniprot: Broad range protease inhibitor.

UniProt ID: Q14508

UniProt Link: https://www.uniprot.org/uniprotkb/Q14508/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: WAP four-disulfide core domain protein 2

Gene name from HGNC: WFDC2 (dJ461P17.6, EDDM4, HE4, WAP5)

HPA class: Cancer-related genes

AlphaFold DB: Q14508

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14508

HPA link: https://www.proteinatlas.org/ENSG00000101443-WFDC2

Tissue specificity RNA from HPA: Tissue enhanced (cervix, salivary gland)

Tissue expression from HPA: Cytoplasmic expression in selected tissues.

Single cell type specificity Cell type enhanced (Club cells, Glandular and luminal cells, Basal respiratory cells, Urothelial cells, Endometrial ciliated cells, Respiratory ciliated cells, Collecting duct cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Secreted

Cancer prognostic summary HPA Prognostic marker in glioma (unfavorable) and renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000101443-WFDC2//pathology/endometrial+cancer

OMIM: 617548

OMIM link2: https://www.omim.org/entry/617548

HGNC ID: HGNC:15939

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939