Biomarker: visfatin

Histology type: endometrial carcinoma

Country: Poland

Region: Szczecin

Followed up time :

Subgroup 1 name : Endometrial cancer

Subgroup 1 number: 78

Subgroup 2 name: Normal endometrium

Subgroup 2 number: 63

Conclusion: High visfatin serum level predicts poor prognosis in endometrial cancer patients.$Kaplan-Meier overall survival curves for endometrial cancer patients based on serum visfatin level.

Sample type : serum

Sample method: multiplex fuorescent beadbased immunoassays

Expression pattern : high /cut-off values for visfatin (20.7 ng/ml)

Expression elevation: The following cut-off values were determined for baseline visfatin levels: median and level of 20.7 ng/ml. Single and multifactorial analysis was performed using the Cox regression model. Multifactorial Cox analysis parameters included age, FIGO, grading, median, and cut-off 20.7 ng/ml visfatin levels.

Funtion Uniprot: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

UniProt ID: P43490

UniProt Link: https://www.uniprot.org/uniprotkb/P43490/entry#function

Biological function from UniProt: Biological rhythms, Pyridine nucleotide biosynthesis

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Subcellular UniProt: #Cytoplasm #Nucleus #Secreted

Alternative name from UniProt:

Catalytic activity: beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamideBy Similarity This reaction proceeds in the backward direction

Gene name from HGNC: NAMPT (PBEF, PBEF1)

HPA link: https://www.proteinatlas.org/ENSG00000105835-NAMPT

Tissue specificity RNA from HPA: Neutrophils - Inflammatory response (mainly)

Tissue expression from HPA: General cytoplasmic expression, highest abundance in lymphoid tissues and gastrointestinal tract. Positivity in plasma.

Subcellular summary HPA Located in Nuclear speckles, Cell Junctions

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), pancreatic cancer (unfavorable), cervical cancer (unfavorable) and head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000105835-NAMPT/tissue

Pathology endo: https://www.proteinatlas.org/ENSG00000105835-NAMPT/tissue/endometrium

Expression figure legend: Visfatin serum levels comparison in individual groups.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817356/figure/fig1/

Survival figure legend: Kaplan-Meier recurrence-free survival curves for endometrial cancer patients based on serum visfatin level.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817356/figure/fig6/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817356/figure/fig7/

HGNC ID: HGNC:30092

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30092