Biomarker: BMP

Histology type: endometrial carcinoma

Country: Sweden

Followed up time :

Conclusion: Our results suggest that BMP signaling promotes EC tumorigenesis, and that TWSG1 antagonizes BMP7 in EC. BMP signaling inhibitors, in combination with chemotherapy, might be useful in the treatment of EC patients.

Funtion description: Ishikawa cells secreted higher amounts of BMP2 compared with ovarian cancer cell lines. Exogenous BMP2 stimulation enhanced EC cell sphere formation via c-KIT induction. BMP2 also induced EMT of EC cells, and promoted migration by induction of SLUG. The BMP receptor kinase inhibitor LDN193189 augmented the growth inhibitory effects of carboplatin. Analyses of mRNAs of several BMP antagonists revealed that TWSG1 mRNA was abundantly expressed in Ishikawa cells. TWSG1 suppressed BMP7-induced, but not BMP2-induced, EC cell sphere formation and migration.

Funtion Uniprot: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).

UniProt ID: P18075

UniProt Link: https://www.uniprot.org/uniprotkb/P18075/entry

Biological function from UniProt: #Chondrogenesis #Differentiation #Osteogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the kidney and bladder. Lower levels seen in the brain.

Subcellular UniProt: #Secreted

Alternative name from UniProt:

Recommended name: Bone morphogenetic protein 7

Gene name from HGNC: BMP7 (OP-1)

HPA class: Intracellular,Secreted

AlphaFold DB: P18075

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P18075

Developmental stage: Expressed in the developing eye, brain and ear during embryogenesis.

HPA link: https://www.proteinatlas.org/ENSG00000101144-BMP7

Tissue specificity RNA from HPA: Tissue enhanced (brain, choroid plexus, thyroid gland)

Single cell type specificity Cell type enhanced (Cytotrophoblasts, Oligodendrocyte precursor cells, Astrocytes, Syncytiotrophoblasts, Basal squamous epithelial cells, Squamous epithelial cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Nucleoli, Vesicles,

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000101144-BMP7/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000101144-BMP7/pathology/endometrial+cancer

Survival figure legend: Overall survival was analyzed using RNA-Seq data of KM plotter, which contained 542 EC patients

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346149/figure/ijms-22-07882-f001/

OMIM: 112267

OMIM link2: https://www.omim.org/entry/112267

HGNC ID: HGNC:1074

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1074