Biomarker: CD8

Histology type: endometrial carcinoma

Country: Korea

Region: Seoul

Study type: retrospective

Followed up time :

Conclusion: The high PD-L1/CD8 ratio and the high expression of PD-L1 on immune cells were independent poor prognostic factors for PFS in endometrial cancer, providing insights into the tumor microenvironment.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : PD-L1/CD8 ratio high on immune cells

Expression elevation: CD8 density was evaluated as the number of CD8-positive T lymphocytes in 10 randomly selected HPFs

Statictics: Mean (SD)

Cohort age: 53.0 ± 10.4

Funtion Uniprot: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

UniProt ID: P01732

UniProt Link: https://www.uniprot.org/uniprotkb/P01732/entry

Biological function from UniProt: #Adaptive immunity #Immunity

Molecular function from UniProt:

Tissue specificity from UniProt: CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation

Subcellular UniProt: #Cell membrane #Membrane #Secreted

Alternative name from UniProt:

Recommended name: T-cell surface glycoprotein CD8 alpha chain

Gene name from HGNC: CD8A (CD8)

HPA class: CD markers Disease related genes Human disease related genes

AlphaFold DB: P01732

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P01732

HPA link: https://www.proteinatlas.org/ENSG00000153563-CD8A

Tissue specificity RNA from HPA: Tissue enriched (lymphoid tissue)

Tissue expression from HPA: Cytoplasmic expression in subsets of immune cells.

Single cell type specificity Group enriched (T-cells, dendritic cells)

Immune cell specificity: Group enriched (memory CD8 T-cell, naive CD8 T-cell, MAIT T-cell）

Subcellular summary HPA Located in Plasma membrane

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (favorable), renal cancer (unfavorable) and cervical cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000153563-CD8A/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000153563-CD8A/pathology/endometrial+cancer

Phenotype ID: 608957

Disease: CD8 deficiency, familial (CD8 deficiency)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 186910

OMIM link1: https://www.omim.org/entry/608957

OMIM link2: https://www.omim.org/entry/186910

HGNC ID: HGNC:1706

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1706