Biomarker: ProGRP

Histology type: endometrioid endometrial carcinoma

Country: Turkey

Region: Ankara

Study type: endometrial biopsy

Followed up time :

Subgroup 1 name : Cancer

Subgroup 1 number: 37

Subgroup 2 name: Control

Subgroup 2 number: 55

Conclusion: Significantly higher ProGRP levels were observed in patients with EA than in controls. Serum ProGRP has good diagnostic sensitivity and specificity for EA.

Sample type : serum

Sample method: chemiluminescent

Expression pattern : higher ProGRP levels>(threshold =20.81 pg/mL)

Expression elevation: The median value of ProGRP was 27.5 pg/mL in EA and the calculated cutoff value was 20.81 pg/mL for diagnosis of EA.

Statictics: Mean (SD)

Subgroup 1 age: 56.0±8.3

Subgroup 2 age: 46.5±6.4

Funtion Uniprot: Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).

UniProt ID: P30550

UniProt Link: https://www.uniprot.org/uniprotkb/P30550/entry#function

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983). In brain, expressed in cells throughout the cortex (PubMed:34610277).

Subcellular UniProt: Located in Plasma membrane (Single cell variability)

Alternative name from UniProt:

Gene name from HGNC: GRPR (BB2, BB2R)

HPA link: https://www.proteinatlas.org/ENSG00000126010-GRPR

Tissue specificity RNA from HPA: Tissue enriched (pancreas)

Subcellular summary HPA #Cell membrane #Membrane #Secreted

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000126010-GRPR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000126010-GRPR/pathology/endometrial+cancer

HGNC ID: HGNC:4609

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4609