Biomarker: GLP-1R

Histology type: endometrial carcinoma

Study type: liraglutide

Followed up time :

Subgroup 1 name : No recurrence

Subgroup 1 number: 57

Subgroup 2 name: Recurrence

Subgroup 2 number: 56

Conclusion: The use of liraglutide to target autophagy in endometrial cancer cells may be a novel potential treatment for endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression(≥6)

Expression elevation: GLP-1R and hormone receptors staining were evaluated according to the Allred score [19], a semi-quantitative system that takes into consideration the proportion of positive cells (scored on a scale of 0–5) and staining intensity (scored on a scale of 0–3). The proportion and intensity scores were added, yielding the Allred score (0–8). The cut-off level for GLP-1R was ≥6, and that for hormone receptors was ≥3, which is the cut-off level usually used in the diagnosis of breast cancer. We divided the samples into two groups, a high expression group and a low expression group. A score ≥ 6 was taken to represent high GLP-1R expression. For hormone receptors, a score ≥ 3 was considered positive.

Statictics: Median;Range

Subgroup 1 age: 65;40–84

Subgroup 2 age: 68;48–88

Funtion Uniprot: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

UniProt ID: P43220

UniProt Link: https://www.uniprot.org/uniprotkb/P43220/entry

Molecular function from UniProt:

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Gene name from HGNC: GLP1R (GLP-1R)

HPA link: https://www.proteinatlas.org/ENSG00000112164-GLP1R

Tissue specificity RNA from HPA: Tissue enhanced (brain, heart muscle, pancreas)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000112164-GLP1R/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000112164-GLP1R/pathology/endometrial+cancer

Expression figure legend: Histopathological presentation of endometrial cancer

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003019/figure/Fig5/

Survival figure legend: Kaplan–Meier survival curves for patients with endometrial cancer according to the degree of GLP-1R expression

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003019/figure/Fig5/

HGNC ID: HGNC:4324

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4324