Biomarker: LCOR

Histology type: endometrioid endometrial carcinoma

Country: Greece

Region: Ioannina

Study type: retrospective study

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 55

Subgroup 2 name: negative

Subgroup 2 number: 38

Conclusion: Our study demonstrated that high cytoplasmic expression of LCOR may predict a longer overall survival of patients with endometrioid endometrial cancer. Patients with tumors expressing low levels of LCOR showed a worse survival compared to those expressing high levels.

Sample type : tissue

Sample method: immunohistochemical staining

Expression pattern : high cytoplasmic expression

Expression elevation: The semi-quantitative immunoreactive score (IRS) was used. The IRS assessed the percentage of positively stained cells (0=no staining, 1≤10% of cells, 2=11-50% of cells, 3=51-80%, and 4≤81% of cells) multiplying the score by the intensity of cell staining (graded as 0=none, 1=weak, 2=moderate, and 3=strong). Therefore, the maximum IRS score was 12.

Statictics: Range

Cohort age: 43-82

Funtion Uniprot: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR

UniProt ID: Q96JN0

UniProt Link: https://www.uniprot.org/uniprotkb/Q96JN0/entry

Biological function from UniProt: Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Ligand-dependent corepressor

Gene name from HGNC: LCOR (C10orf12, DKFZP564P1916, FLJ13022, FLJ38026, KIAA1795, MLR2)

AlphaFold DB: Q96JN0

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q96JN0

HPA link: https://www.proteinatlas.org/ENSG00000196233-LCOR

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear and cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Oligodendrocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in urothelial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000196233-LCOR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000196233-LCOR/pathology/endometrial+cancer;

Expression figure legend: A slight positivity of NRIP1 expression was observed not only in cancer tissue, but also in some stromal cells of the endometrium

Expression figure link: https://iv.iiarjournals.org/content/invivo/35/5/2631/F1.large.jpg

Survival figure legend: Overall survival for patients with low (≤2) and high (>2) immunoreactive scores for expression of cytoplasmic ligand-dependent co-repressor (LCOR)

Survival curve link: https://iv.iiarjournals.org/content/invivo/35/5/2631/F3.large.jpg

OMIM: 607698

OMIM link2: https://www.omim.org/entry/607698

HGNC ID: HGNC:29503

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29503