Basic information
Biomarker: MMP20
Histology type: endometrial carcinoma
Cohort characteristics
Region: guangzhou
Followed up time :
Subgroup 1 name : High expression
Subgroup 1 number: 43
Subgroup 2 name: Low expression
Subgroup 2 number: 91
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 210 | fresh endometrial carcinoma | 21 | fresh adjacent endometrial tissues | 21 | paraffin-embedded endometrial carcinoma tissues | 134 | paraffin-embedded endometrial tissues | 34 |
Sample information
Conclusion: High expression of MMP20 is a potential prognostic factor for poor outcomes of patients with endometrial carcinoma.
Sample type : tissue
Sample method: Real-time PCR/immunohistochemistry
Expression pattern : high expression(>6)
Expression elevation: Ten high-power fields (×400) were randomly selected and scored according to the number of positive cells and coloring intensity. The proportion of positive cells was 0 points for no positive cells, 1 point for < 10%, 2 for 10%-50%, and 3 for >50%.>75% is 4 ; Color intensity: No color is 0 points, light yellow is 1, brown yellow is 2, brown is 3.
Disease information
Statictics: Range
Cohort age: 27-82
Related information
Funtion Uniprot: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
UniProt ID: O60882
UniProt Link: https://www.uniprot.org/uniprotkb/O60882/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed specifically in the enamel organ.Expression initiates prior to the onset of dentin mineralization and continues throughout the secretory stage of amelogenesis.
Subcellular UniProt: #Extracellular matrix #Secreted
Alternative name from UniProt:
Gene name from HGNC: MMP20
HPA link: https://www.proteinatlas.org/ENSG00000137674-MMP20
Tissue specificity RNA from HPA: Not detected
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000137674-MMP20/tissue
Pathology endo: https://www.proteinatlas.org/ENSG00000137674-MMP20/tissue/endometrium
Expression figure legend: Immunohistochemistry for detecting the expression of MMP20 protein in endometrial carcinoma and endometrial tissues (Original magnification: ×400).
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744060/figure/Figure3/
Survival figure legend: A high expression of MMP20 mRNA is associated with a poor prognosis in patients with endometrial carcinoma.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744060/figure/Figure1/
HGNC ID: HGNC:7167
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7167
