Basic information
Biomarker: MMR
Histology type: endometrial carcinoma
Cohort characteristics
Region: Thessaloniki
Followed up time :
Subgroup 1 name : Deficiency
Subgroup 1 number: 81
Subgroup 2 name: Proficiency
Subgroup 2 number: 97
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 204 | endometrial cancer | 204 |
Sample information
Conclusion: MMRd may serve as independent prognostic factors for recurrence and survival in patients with endometrial cancer.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : MMR deficient
Expression elevation: MMR evaluation was based on the detection of four MMR proteins (MLH1, MSH2, MSH6 and PMS2), which were considered positive if ≥10% positive nuclei with mild to strong intensity were encountered. Tumors with a negative result in one of the four proteins were characterized as MMR deficient (MMRd)
Disease information
Statictics: Mean;Range
Cohort age: 63.9;29–87
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Characteristic examples of negative and positive protein markers with IHC.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g002/
Survival figure legend: Evaluation of Jag1-Notch pathway activation patterns.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g003/
