Basic information
Biomarker: Jag1
Histology type: endometrial carcinoma
Cohort characteristics
Region: Thessaloniki
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 204 | endometrial cancer | 204 |
Sample information
Conclusion: Aberrant expression of key components of the Notch and Hedgehog signaling pathways, as well as MMRd may serve as independent prognostic factors for recurrence and survival in patients with endometrial cancer.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : positive (range 3–12)
Expression elevation: Staining intensity for Notch2, Notch3 and Jag1 was scored into four grades (0, 1+, 2+ and 3+), while the percentage of positive cells was also scored into four categories (0 for 0%, 1 for 1–33%, 2 for >33–66% and 3 for >66–100%). The product of intensity and percentage categories (range 0–9) was finally classified as negative (0–4) and positive (5–9) . Similarly, for Gli, Patched-1, Shh and Smo, intensity was scored into four grades (0, 1+, 2+ and 3+), while the percentage of positive cells was scored into five categories (0 for <5%, 1 for 5–25%, 2 for >25–50%, 3 for >50–75% and 4 for >75%). The product of the intensity and percentage categories (range 0–12) was used as the final score and classified as negative (0–2) and positive (3–12).
Disease information
Statictics: Mean;Range
Cohort age: 63.9;29–87
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Characteristic examples of negative and positive protein markers with IHC.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g002/
Survival figure legend: Evaluation of Jag1-Notch pathway activation patterns.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g003/
