Basic information
Biomarker: IMP3
Histology type: endometrial serous carcinomas
Cohort characteristics
Country: Japan
Region: Suzuka
Followed up time :
Subgroup 1 name : positive in EC
Subgroup 1 number: 41
Subgroup 2 name: positive in control
Subgroup 2 number: 0
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 333 | EAC | 97 | serous carcinoma (ESC) | 35 | benign endometrial samples | 201 |
Sample information
Conclusion: IMP3 is a helpful immunomarker to distinguish ESC from EAC and SPSC in endometrial cytology.（endometrioid adenocarcinoma (EAC), serous carcinoma (ESC) and surface papillary syncytial change (SPSC)）
Sample type : cytology
Sample method: immunohistochemistry
Expression pattern : expression(score ≥3)
Expression elevation: The staining intensity was classified as follows: absent=0, weak=1+, moderate=2+ and strong=3+ reaction and the frequency of positive staining cells was classified as 0%=0, 1-5%=1, 6-50%= 2 and >50% stained/% cells=3. For statistical analysis, a quantitative scoring method (percentage × intensity) was used, and it ranged from 0 to 9, as previously described. Any score ≧3 was considered to be positive.
Disease information
Related information
Funtion Uniprot: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
UniProt ID: Q9NV31
UniProt Link: https://www.uniprot.org/uniprotkb/Q9NV31/entry
Biological function from UniProt: Ribosome biogenesis, rRNA processing
Molecular function from UniProt:
Subcellular UniProt: Nucleus
Alternative name from UniProt:
Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3
Gene name from HGNC: IMP3 (BRMS2, C15orf12, FLJ10968, MRPS4)
HPA class: Plasma proteins Ribosomal proteins
AlphaFold DB: Q9NV31
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NV31
HPA link: https://www.proteinatlas.org/ENSG00000177971-IMP3
Tissue specificity RNA from HPA: Low tissue specificity
Single cell type specificity Low cell type specificity
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology/endometrial+cancer
OMIM: 612980
OMIM link2: https://www.omim.org/entry/612980
HGNC ID: HGNC:14497
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14497
