Biomarker: endothelial (CD144+)

Histology type: endometrial carcinoma

Country: Poland

Region: Cracow

Followed up time :

Subgroup 1 name : Endometrial cancer

Subgroup 1 number: 37

Subgroup 2 name: Healthy controls

Subgroup 2 number: 23

Conclusion: The most interesting finding in this work was the high level of TF, CD144 and CD14 MPs in uterine blood samples. Thus we can consider the monocyte-macrophage-derived MPs as a candidate marker of endometrial cancer and maybe very critical part of the endometrial carcinogenesis.

Sample type : plasma

Sample method: flow cytometry

Expression pattern : high level

Funtion Uniprot: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).

UniProt ID: P33151

UniProt Link: https://www.uniprot.org/uniprotkb/P33151/entry

Biological function from UniProt: Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Endothelial tissues and brain.

Subcellular UniProt: Cell junction #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Cadherin-5

Gene name from HGNC: CDH5 (7B4, CD144)

CD antigen name: CD144

HPA class: Cancer-related genes CD markers Plasma proteins

AlphaFold DB: P33151

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P33151

Tissue specificity RNA from HPA: Tissue enhanced (placenta)

Tissue expression from HPA: Cytoplasmic expression in several different tissue types.

Single cell type specificity Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Late spermatids, Syncytiotrophoblasts)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Nuclear membrane, Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000179776-CDH5/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000179776-CDH5/pathology/endometrial+cancer

OMIM: 601120

OMIM link2: https://www.omim.org/entry/601120

HGNC ID: HGNC:1764

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1764