Biomarker: SNF5

Histology type: endometrial carcinoma

Country: Chinese

Region: Shengjing

Followed up time :

Subgroup 1 name : Positive in EC

Subgroup 1 number: 30

Subgroup 2 name: positive in non-EC

Subgroup 2 number: 16

Conclusion: Our results indicate that SNF5 plays an important role of promoting oncogenesis in EC. These findings open up the possibility for various novel and effective combination therapies targeting SNF5 in the EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression(the final score was the product of the density score and the percentage score (ranging from 0 to 12),scores that ranged from 8 to 12 were considered as positive expression)

Expression elevation: The intensity of the stain was ranged from 0 to 3: 0 no staining intensity; 1 weak stained; 2 and 3 were defined as moderate and strong stained, respectively. The proportion of stained present was scored subjectively as 0 (0–5% staining), 1 (6–25% staining), 2 (26–50% staining), 3 (51–75% staining) and 4 (75–100% staining). The final score was the product of the density score and the percentage score (ranging from 0 to 12).

Statictics: Median;Range

Cohort age: 59.5;39–80

Funtion Uniprot: Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

UniProt ID: Q9Z0H3

UniProt Link: https://www.uniprot.org/uniprotkb/Q9Z0H3/entry

Biological function from UniProt: Cell cycle, Host-virus interaction, Neurogenesis, Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at 10.5 dpc-16.5 dpc

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Gene name from HGNC: SMARCB1 (BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1)

HPA class: Cancer-related genes Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: Q9Z0H3

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9Z0H3

HPA link: https://www.proteinatlas.org/ENSG00000099956-SMARCB1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous nuclear expression.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low human brain regional specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli fibrillar center

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000099956-SMARCB1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000099956-SMARCB1/pathology/endometrial+cancer

Expression figure legend: Representative immunohistochemical staining of RRBP1 in endometrial endometrioid adenocarcinoma specimens

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347782/figure/Fig2/

Survival figure legend: Kaplan-Meier analysis of overall survival and disease-free survival related to the expression of RRBP1.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347782/figure/Fig3/

HGNC ID: HGNC:11103

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11103