Basic information
Biomarker: IMP3
Histology type: endometrial carcinoma
Stage: grade 2
Cohort characteristics
Country: Netherlands
Region: Nijmegen
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 378 | EC |
Sample information
Conclusion: We recommend use of a panel of at least two easily accessible immunohistochemical biomarkers (PR and p53), only in grade 2 ECs
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : PR+IMP3+L1CAM
Expression elevation: The staining index (0-9) was obtained by the product of intensity, graded from 0 (no staining), 1 (weak staining), 2 (moderate staining) to 3 (strong staining), and area of tumor with this staining intensity, graded from 0 (no positive tumor cells), 1 (1-10% positive tumor cells), 2 (11-50% positive tumor cells) to 3 (>50% positive tumor cells).
Disease information
Related information
Funtion Uniprot: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
UniProt ID: Q9NV31
UniProt Link: https://www.uniprot.org/uniprotkb/Q9NV31/entry
Biological function from UniProt: Ribosome biogenesis, rRNA processing
Molecular function from UniProt:
Subcellular UniProt: Nucleus
Alternative name from UniProt:
Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3
Gene name from HGNC: IMP3 (BRMS2, C15orf12, FLJ10968, MRPS4)
HPA class: Plasma proteins Ribosomal proteins
AlphaFold DB: Q9NV31
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NV31
HPA link: https://www.proteinatlas.org/ENSG00000177971-IMP3
Tissue specificity RNA from HPA: Low tissue specificity
Single cell type specificity Low cell type specificity
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology/endometrial+cancer
OMIM: 612980
OMIM link2: https://www.omim.org/entry/612980
HGNC ID: HGNC:14497
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14497
