Biomarker: KLF11

Histology type: endometrioid endometrial carcinoma

Country: Italy

Region: Udine

Study type: Retrospective observational study

Followed up time :

Conclusion: In patients affected by endometrioid endometrial carcinoma, higher staining levels of KLF11 correlated with a poorer prognosis. However, further studies are required in order to better clarify the role of KLFs in the natural history of endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high nuclear (high H-score = above the 50th percentile of the distributionlear expression

Expression elevation: Immunohistochemical staining was evaluated in terms of H-score (the product of the actual percentage of positivestained cells and intensity score - evaluated as strong 3, moderate 2 and weak 1 – giving a possible range of 0–300) except for Ki-67 which was evaluated as a percentage of positive nuclei.

Statictics: Mean (SD)

Cohort age: 65.6±10.2

Funtion Uniprot: Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).

UniProt ID: O14901

UniProt Link: https://www.uniprot.org/uniprotkb/O14901/entry

Biological function from UniProt: #Apoptosis #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous. Higher expression in erythroid cells

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Caution: PubMed:11087666 sequence was originally thought to originate from mouse.

Recommended name: Krueppel-like factor 11

Gene name from HGNC: KLF11 (MODY7, TIEG2, Tieg3)

HPA class: Disease related genes Human disease related genes Transcription factors

AlphaFold DB: O14901

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O14901

Induction: By TGFB1.

HPA link: https://www.proteinatlas.org/ENSG00000172059-KLF11

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Cell type enhanced (Early spermatids, Suprabasal keratinocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nuclear bodies, Focal adhesion sites, Cytosol (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000172059-KLF11/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000172059-KLF11/pathology/endometrial+cancer

Phenotype ID: 610508

Disease: Maturity-onset diabetes of the young 7 (MODY7)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 603301

OMIM link1: https://www.omim.org/entry/610508

OMIM link2: https://www.omim.org/entry/603301

HGNC ID: HGNC:11811

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11811