Biomarker: KLF5

Histology type: endometrioid endometrial carcinoma

Country: Italy

Region: Udine

Study type: Retrospective observational study

Followed up time :

Conclusion: In patients affected by endometrioid endometrial carcinoma, higher staining levels of KLF5 correlated with a poorer prognosis. However, further studies are required in order to better clarify the role of KLFs in the natural history of endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high H-score = above the 50th percentile of the distribution

Expression elevation: Immunohistochemical staining was evaluated in terms of H-score (the product of the actual percentage of positivestained cells and intensity score - evaluated as strong 3, moderate 2 and weak 1 – giving a possible range of 0–300) except for Ki-67 which was evaluated as a percentage of positive nuclei.

Statictics: Mean (SD)

Cohort age: 65.6±10.2

Funtion Uniprot: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

UniProt ID: Q13887

UniProt Link: https://www.uniprot.org/uniprotkb/Q13887/entry

Biological function from UniProt: Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed only in testis and placenta.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Krueppel-like factor 5

Gene name from HGNC: KLF5 (BTEB2, CKLF, IKLF)

HPA class: Cancer-related genes Transcription factors

AlphaFold DB: Q13887

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q13887

HPA link: https://www.proteinatlas.org/ENSG00000102554-KLF5

Tissue specificity RNA from HPA: Tissue enhanced (esophagus, skin)

Tissue expression from HPA: Mainly nuclear expression in most tissues.

Single cell type specificity Cell type enhanced (Urothelial cells, Basal prostatic cells, Squamous epithelial cells, Basal squamous epithelial cells, Suprabasal keratinocytes, Glandular and luminal cells)

Immune cell specificity: Immune cell enriched (basophil)

Subcellular summary HPA Located in Nucleoplasm, Golgi apparatus, Vesicles

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000102554-KLF5/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000102554-KLF5/pathology/endometrial+cancer

OMIM: 602903

OMIM link2: https://www.omim.org/entry/602903#

HGNC ID: HGNC:6349

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6349