Basic information
Biomarker: Patched-1
Histology type: endometrial carcinoma
Cohort characteristics
Region: Thessaloniki
Followed up time : median follow-up of 72 month
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 204 | endometrial cancer | 204 |
Sample information
Description: Aberrant expression of key components of the Notch and Hedgehog signaling pathways, as well as MMRd may serve as independent prognostic factors for recurrence and survival in patients with endometrial cancer.
Sample type : tissue
Disease information
Statictics: Mean;Range
Cohort age: 63.9;29–87
Related information
Survival figure legend: Evaluation of the Hedgehog pathway activation patterns.
Survival figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g004/
Expression figure legend: Characteristic examples of negative and positive protein markers with IHC.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283658/figure/pone.0208221.g002/
Description: Protein patched homolog 1 is a protein that is the member of the patched family and in humans is encoded by the PTCH1 gene.PTCH1 is a member of the patched gene family and is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene functions as a tumor suppressor. The PTCH1 gene product, is a transmembrane protein that suppresses the release of another protein called smoothened, and when sonic hedgehog binds PTCH1, smoothened is released and signals cell proliferation.
