Pubmed Biomarker Relation Odds
(95% CI)		 P-value Description
34109467 HE4 deep myometrial invasion p=0.001 Serum HE4 levels was significantly associated with deep myometrial invasion
32433831 COX-2 myometrial invasion p<.001 In 20/52 (38.5%) cases with myometrial invasion >1/2, there was positive expression of COX-2 in contrast to 11/74 (14.9%) cases with depth of myometrial invasion <1/2
30684972 RRBP1 myometrial invasion p<0.001 High levels of expression of RRBP1 were strongly correlated with deep muscular layer infiltration
30539847 HIF-1α myometrial invasion p=0.012 HIF-1α expression was significantly associated with depth of myometrial invasion
29895385 The signal intensity (SI) myometrial invasion p=0.006 The SI ratio of the tumour to the myometrium showed that lower T2 tumour/T2 myometrial ratio correlated with ≥50% depth of myometrial invasion as determined by imaging
29526558 TRIM44 myometrial invasion p<0.05 TRIM44 overexpression was associated with depth of myometrial invasion
29516012 visfatin myometrial invasion p=0.004 Significantly higher concentrations of visfatin have been observed in patients with the depth of infiltration of the endometrium
29516012 visfatin depth of infiltration of the endometrium p=0.004 Significantly higher concentrations of visfatin have been observed in patients with the depth of infiltration of the endometrium
28980703 IRAK1 myometrial invasion p<0.05 Fisher’s exact test indicated that IRAK1 expression level was significantly correlated with myometrial invasion
28800309 CA125 myometrial invasion According to the ROC curve, the suitable cut-off value for CA125 in myometrial invasion equal to or greater than 50% (sensitivity = 64%, specificity = 61%, positive predictive value = 47%, negative predictive value = 74%) was 20 u/ml.(sensitivity = 64%, specificity = 61%, positive predictive value = 47%, negative predictive value = 74%)
28668893 E-cadherin myometrial invasion p=0.049 E-cadherin expression was significantly positively correlated with myometrial invasion
33832498 mesothelin myometrial invasion p=0.016 More patients with co-expression of mesothelin and CA125 had myometrial invasion of more than 50%
28668893 β-Catenin myometrial invasion p=0.004 β-Catenin expression was also significantly positively correlated with myometrial invasion
28401338 HE4 myometrial invasion p<0.001 Serum HE4 concentration is significantly associated with deep myometrial invasion
28401338 HE4 myometrial invasion p=0.01 Serum HE4 concentration is significantly associated with exact depth of myometrial invasion (≥4 mm)
27549092 CA-125 myometrial invasion R = 0.528 p=0.01 The degree of myometrial invasion (cm) was significantly correlated with CA-125 values
27340318 IL-33 depth of invasion p=0.008 Serum IL-33 was close to the disease process: depth of invasion
27124937 IFITM1 myometrial invasion IFITM1 had 71.4% sensitivity and 100% specificity in detecting stroma surrounding endometrioid adenocarcinoma, hence excluding myoinvasion.(71.4% sensitivity and 100% specificity)
27039795 HE4 myometrial invasion r=0.46 p<0.001 Preoperative serum HE4 levels were strongly correlated with moderately correlated with depth of myometrial invasion
27039795 HE4 myometrial invasion p=0.004 Serum HE4 levels were significantly elevated in EC patients with depth of myometrial invasion > 50%
26985869 c-erbB-2 myometrial invasion p=0.007 C‑erbB‑2 expression was significantly lower in endometrial carcinoma with depth of myometrial invasion <0.4 cm
26985869 c-erbB-2 myometrial invasion p=0.003 The analysis demonstrated that the levels of c-erbB-2 mRNA were higher in deeper invasion compared with depth of myometrial invasion <0.4 cm.(2.323±1.264 vs. 4.263±1.250)
33635467 BMP-10 myometrial invasion p<0.001 BMP-10 expression was significantly correlated with myometrial invasion depth
26985869 c-erbB-2 deeper invasion p=0.033 The analysis demonstrated that the levels of c-erbB-2 mRNA were higher in deeper invasion , compared with no deeper invasion .(2.459±1.307 vs. 4.028±1.397)
26925634 CA-125 myometrial invasion p<0.05 The presence of deep myometrial invasion and CA-125 cut-off values (16, 20, 35 IU/ml)
26708131 Co-expression GAL-3 and CRIP-1 myometrial invasion aOR 0.32 There was a significant correlation between high co-expression of the two proteins and the tumor depth
26608413 CD44 myometrial invasion p=0.034 CD44 expression decreased were correlated with myometrial invasive depth
26362938 ANXA2 myometrial invasion p < 0.05 The high expression rate of ANXA2 in the deep myometrial invasion group was 81.8 % (27/33), which was significantly higher than the superficial myometrial invasion group (54.9 % [28/51]
26362938 HE4 myometrial invasion  p < 0.05 The high expression rate of HE4 in the deep muscular layer invasion group was 63.6 % (21/33), which was significantly higher than the superficial myometrial invasion group (33.3 % [17/51];
26166558 LSD1 deep myometrial invasion p=0.013 LSD1 overexpression was significantly associated with the advanced extent of EEA,a deep myometrial invasion .
26045311 MTV (metabolic tumor volume ) myometrial invasion OR: 7.8 confidence interval [CI], 3.2–19.1 p<0.001 Optimal cutoffs for MTV in predicting deep myometrial invasion (20 mL)
26045311 MTV myometrial invasion/high risk OR of 7.3 (CI, 2.9–18.3) p<0.001 adjusting for preoperative biopsy results suggesting high risk (nonendometrioid subtype or endometrioid grade 3), an MTV cutoff of 20 mL yielded an OR of 7.3 (CI, 2.9–18.3; P < 0.001) for deep invasion
26045311 SUVmean myometrial invasion p<0.015 SUVmean were significantly related to deep myometrial invasion and independently predicted deep myometrial invasion after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
33235117 TWIST1 deep myometrial invasion p = .007 Increased TWIST1 expression was significantly associated with deep myometrial invasion
26045311 SUVmean myometrial invasion p<0.015 SUVmeanwere significantly related to deep myometrial invasion and independently predicted deep myometrial invasion after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
26045311 SUVmax (standardized uptake value) myometrial invasion p<0.015 SUVmax were significantly related to deep myometrial invasion and independently predicted deep myometrial invasion after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
26045311 MTV myometrial invasion ROC curves showed that MTV had the highest areas under the curve: 0.77 in predicting deep myometrial invasion
25951350 Enolase-1 myometrial invasion p=0.033  The expression level of ENO1 was positively correlated with depth of myometrial invasion
25874492 Sam68 myometrial invasion p=0.002 The high expression of Sam68 was associated with myometrial invasion
25613390 G9a deep myometrial invasion 95 % confidence interval, 0.55–0.78 An optimum G9a staining index cutoff value of 3 or higher was determined to predict deep myometrial invasion, which yields an area under the ROC curve of 0.67.(ROC curve of 0.67 ,sensitivity, 72 %; specificity, 58 %)
25544793 ZEB1 myometrial invasion p=0.014 The ZEB1 expression in endometrial biopsy significantly associated with myometrial invasion
25355598 HABP1 deep myometrial invasion p=0.013 High HABP1 expression was significantly associated with deep myometrial invasion
24692842 HDGF myometrial invasion p=0.016 High HDGF protein expression was significantly associated with the survival time for EC patients based on depth of myometrial invasion (≧1/2)
24590269 TNFAIP8 deep myometrial invasion p=0.030 An association was observed between TNFAIP8 overexpression and deep myometrial invasion
33156532 HE4 myometrial invasion p=0.001 A statistically significant association was found between the preoperative HE4 value and deep myometrial invasion
24211402 Serum HE4 myometrial invasion p<0.001 Median CA125 and HE4 levels were higher in tumours with outer-half myometrial invasion
24067230 Pin1 myometrial invasion Pin1 expression was negatively correlated with invasive depth of myometrium.
23617619 core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) myometrial invasion (p<0.0005 C2GnT1 was strongly expressed at sites of deep myometrial invasion. In addition, patients with C2GnT1 overexpression (PI ≥ 10) had significantly shorter survival ).
23438672 Visfatin myometrial invasion p=0.023 High visfatin expression in EC tissues was significantly associated with myometrial invasion ≥1/2
23200913 GRP78 myometrial invasion p=0.004 High visceral adipocyte GRP78 expression positively correlated with deep myometrial invasion
23114646 EMT myometrial invasion p<0.01 EMT status, which was represented by both reduced E-cadherin and nuclear expression of Snail, was significantly associated with myometrial invasion,
22198340 tumor budding (TB) myometrial invasion  p= 0.018 The high-grade TB was significantly higher in patients with deep myometrial invasion
22116456 endoglin myometrial invasion p<0.001 Increase in endoglin protein expression seems to be associated with increased malignancy of tumor cells estimated by depth of myometrial invasion.
22015044 Synuclein-γ (SNCG) protein myometrial invasion p=0.031 There was a strong association between SNCG+ and deep myometrial invasion
22008707 ADCmin myometrial invasion p<0.001 There were significant correlations between the ADCmin of the primary tumor and depth of myometrial invasion
32769331 TROP2 myometrial invasion p≤0.05 High overexpression of TROP2 was seen in deeper-invasive tumors
21764107 SUVmax myometrial invasion p=0.031 There were significant correlations between the SUVmax of the primary tumor and depth of myometrial invasion
21741077 Beclin 1 myometrial invasion A high Beclin 1 reactivity occurred in 18.1% of endometrial adenocarcinomas studied and was associated with high myometrial invasion
18475299 BMI-1 myometrial invasion p=0.004 BMI-1 protein expression was significantly weaker in tumours with deep myometrial infiltration
18313673 aquaporin-1 (AQP1) myometrial invasion p<0.05 The AQP1/IMD ratio was significantly higher for lesions from the women with deep myometrial invasion than for those with superficial myometrial invasion or no myometrial invasion
18289648 TAMs myometrial invasion p=0.0001 Margin TAMs were significantly associated with myometrial invasion
18289648 TAMs myometrial invasion HR, 4.03; 95% CI, 1.06-14.71 p=0.041 On multivariate analysis, high margin TAMs were significantly associated with myometrial invasion
17527071 MSI myometrial invasion p=0.040 The MSI-high phenotype was related with the presence of deep myometrial invasion
17260229 CA-125 myometrial invasion p=0.001 Elevated serum CA-125 levels were significantly correlated with  increased depth of myometrial invasion
17130035 oestrogen receptor myometrial invasion p<0.001 As the depth of myometrial invasion increased, the tumour was found to show less oestrogen receptor expression
17108150 ephrinB2 myometrial invasion p<0.01 Both the histoscores and mRNA levels of ephrinB2 significantly increased with myometrial invasion (A < B < C
32769331 TROP2 myometrial invasion High overexpression of TROP2 was seen in deeper-invasive tumors
17108150 EphB4 myometrial invasion p<0.05 Both the histoscores and mRNA levels of EphB4 significantly increased with myometrial invasion (A < B < C
16681769 ERRalpha and ERRgamma myometrial invasion p=0.043 Expression of ERRalpha mRNA was positively correlated with myometrial invasion
16564917 Twist myometrial invasion p=.012 High Twist expression was significantly associated with deep myometrial invasion (>1/2)
16014121 c-FLIP myometrial invasion p<0.05 c-FLIP association with myometrial invasion was marginal
16014121 c-FLIP myometrial invasion p<0.05 The expression levels of c-FLIP protein were significantly higher in carcinomas with presence of invasion to >1/2 myometrium than <1/2 ones.Multivariate analysis of variance confirmed that the expression levels of c-FLIP the influence of myometrial invasion was marginal
15363194 P53 myometrial invasion P53 expression was associated with depth of myometrial invasion in EC
15363194 C-erbB-2 myometrial invasion p<0.005 C-erbB-2 expression was associated with depth of myometrial invasion in EC
15328195 E-Cadherin myometrial invasion Kendall tau: 0.30 p<0.01 E-Cadherin expression was positively correlated with myometrial invasion
15218296 placental leucine aminopeptidase myometrial invasion p=0.01 There was a positive correlation between the expression of P-LAP and myometrial invasion
15025952 cFLIP myometrial invasion p<0.05 cFLIP expression was also significantly associated with the presence of invasion to >1/2 myometrium
32594230 ARID1A myometrial invasion p=0.047 MELF-type myometrial invasion pattern was more common in tumors with ARID1A loss
14976916 uPA myometrial invasion Higher uPA expression was associated with deeper myometrial invasion while, in endometrial tumors with unfavorable prognosis,
12866577 HER-2:CEP17 ratio myometrial invasion p=0.010 HER-2 amplification was significantly correlated with myometrial invasion
12866577 HER-2:CEP17 ratio myometrial invasion p=0.004 Chromosome 17 polisomy showed a positive correlation only with myometrial invasion
12819391 endoglin (CD105) myometrial invasion p<0.01 There was a positive correlation of both endoglin and the depth of invasion
12798703 Elf-1 myometrial invasion p<0.01 Scoring on the basis of the percentage of nuclear-positive cells indicated that nuclear Elf-1 expression was significantly associated with the presence of invasion to greater than one-half the myometrium.
12525874 CaMKIV myometrial invasion p=0.02 CaMKIV expression was significantly associated with myometrial invasion (no myometrial invasion versus the presence of invasion to greater than one-half the myometrium;
11275368 Id1 myometrial invasion p<0.05 Scoring on the basis of the percentage of positive cells indicated that Id1 expression is significantly associated with the presence of invasion to >1/2 myometrium
10427121 KGFR myometrial invasion The results showed that KGFR expression increased with the stage of the tumor and that the simultaneous overexpression of the three growth factor receptors appeared to be related to the depth of myometrial invasion.
9934583 Ki-S4 PA myometrial invasion p=0.03 Relative to the median PA, a signi®cant difference was found between tumours revealing myometrial invasion # 50% vs. > 50%
9648591 PR myometrial invasion p=0.006 PR immunohistochemistry of endometrial carcinoma was statistically correlated with the depth of myometrial tumor invasion (< or = 1/2 vs > 1/2,
32594230 ARID1A myometrial invasion p=0.047 MELF-type(microcystic elongated and fragmented) myometrial invasion pattern was more common in tumors with ARID1A loss
9648591 ER myometrial invasion p=0.026 ER immunohistochemistry had significant correlations with the depth of myometrial tumor invasion
9648586 CA125 myometrial invasion A novel cutoff level of 20 U/ml of CA125 could detect myometrial invasion to more than one-half of the myometrium with sensitivity of 69.0%, specificity of 74.1%, positive predictive value of 58.8%, and negative predictive value of 81.6%.
9038731 CA 72-4 myometrial invasion p<0.05 Serum CA72-4 positivity was correlated with depth of myometrial invasion
8697392 desmoplakin I myometrial invasion The expression was lower in cases of was lower in the cases with > one-half myometrial invasion than in cases with < one-half myometrial invasion.
8697392 desmoplakin II myometrial invasion The expression was lower in cases of lymph node metastasis than in negative cases and was lower in the cases with > one-half myometrial invasion than in cases with < one-half myometrial invasion.
8137210 OVX1 myometrial invasion p<0.01 Elevation of serum OVX1 was found more frequently in patients with deep myometrial invasion and with poorly differentiated tumors
8664123 cathepsin D myometrial invasion The expression was lower in cases of lymph node metastasis than in negative cases and was lower in the cases with > one-half myometrial invasion than in cases with < one-half myometrial invasion.
36721236 SLERT P < 0.001 SLERT was significantly correlated with depth of invasion

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