Biomarker: C22-ceramides

Histology type: endometrioid endometrial carcinoma

Country: Slovenia

Region: Maribor

Study type: prospective study

Followed up time :

Subgroup 1 number: endometrial cancer

Subgroup 2 name : no malignancie

Subgroup 1 number: 15

Subgroup 2 number: 21

Cohort statistics: Mean (SD)

Description: C22-ceramides identified as potential diagnostic biomarkers for EC. Additionally, these identified metabolites may provide additional insight into cancer cell metabolism.

Sample type : serum

Sample method: HPLC-TQ/MS

Subgroup 1 age: 64±14

Subgroup 2 age: 54±19

Expression figure legend: ROC curves and boxplot representations for 4 top performing biomarkers as analyzed by univariate analysis.

Expression figure link: https://ars.els-cdn.com/content/image/1-s2.0-S1896112620300456-gr4_lrg.jpg

Status: Detected and Quantified

HMDB ID: HMDB0004952

Secondary accession numbers: HMDB04952

Common name: Cer(d18:1/22:0)

Description: Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935 ) and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID 14998372 ). Is key in the biosynthesis of glycosphingolipids and gangliosides.

Chemical formula: C40H79NO3

Chemical taxonomy description: Belongs to the class of organic compounds known as ceramides. These are lipid molecules containing a sphingosine in which the amine group is linked to a fatty acid.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Sphingolipids

Chemical taxonomy sub class: Ceramides

Direct parent: Ceramides

Alternative parents: N-acyl amines Secondary carboxylic acid amides Secondary alcohols Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds

Substituents: Ceramide Fatty amide N-acyl-amine Fatty acyl Carboxamide group Secondary alcohol Secondary carboxylic acid amide Carboxylic acid derivative Primary alcohol Organooxygen compound Organonitrogen compound Organic oxide Organopnictogen compound Organic oxygen compound Alcohol Organic nitrogen compound Carbonyl group Hydrocarbon derivative Aliphatic acyclic compound

Molecular framework: Aliphatic acyclic compounds

Disposition: Biological location Cellular substructure: Extracellular Non-excretory biofluid: Blood Excreta:Feces Organ: Brain, Intestine, Kidney, Liver, Pancreas, Placenta, Spleen, Gland,Thyroid gland Tissue:Epithelium( Epidermis) Muscle tissue: Skeletal muscle Cell: Neuron Hematocyte Platelet

Associated disorders diseases: # Colorectal cancer [PubMed:27275383 ]

KEGG compound ID: C00195

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C00195

HMDB link: https://hmdb.ca/metabolites/HMDB0004952