Biomarker: Usodeoxycholic acid

Histology type: endometrial carcinoma

Stage: early-stage EC

Country: China

Region: Jiangsu

Followed up time :

Description: In conclusion, we established a novel and non-invasive lipid biomarker for early-stage EC detection and these findings may provide new insight into the pathological mechanisms of EC.

Sample method: UHPLC-MS/MS

Status: Detected and Quantified

HMDB ID: HMDB0000946

Secondary accession numbers: HMDB0015525 HMDB00946 HMDB15525

Common name: rsodeoxycholic acid

Description: Ursodeoxycholic acid, also known as ursodeoxycholate or acid deoxyursocholic, belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. Dihydroxy bile acids, alcohols and derivatives are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups. Ursodeoxycholic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral.

Chemical formula: C24H40O4

Chemical taxonomy description: Belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. Dihydroxy bile acids, alcohols and derivatives are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Bile acids, alcohols and derivatives

Direct parent: Dihydroxy bile acids, alcohols and derivatives

Alternative parents: 7-alpha-hydroxysteroids 3-alpha-hydroxysteroids Secondary alcohols Cyclic alcohols and derivatives Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds

Substituents: Dihydroxy bile acid, alcohol, or derivatives 3-hydroxysteroid 7-hydroxysteroid 7-alpha-hydroxysteroid 3-alpha-hydroxysteroid Hydroxysteroid Cyclic alcohol Secondary alcohol Carboxylic acid derivative Carboxylic acid Monocarboxylic acid or derivatives Organic oxide Alcohol Organic oxygen compound Carbonyl group Hydrocarbon derivative Organooxygen compound Aliphatic homopolycyclic compound

Molecular framework: Aliphatic homopolycyclic compounds

Physiological effect: bitter

Disposition: bitteOrgan substructure Adrenal Cortex (HMDB: HMDB0000946) Organ Bladder (HMDB: HMDB0000946) Intestine (HMDB: HMDB0000946) Liver (HMDB: HMDB0000946) Placenta (HMDB: HMDB0000946) Cell Fibroblasts (HMDB: HMDB0000946) Tissue Muscle tissue Skeletal Muscle (HMDB: HMDB0000946) Non-excretory biofluid Biofluid or Excreta Blood (PMID: 15185309 ) Excreta Biofluid or Excreta Urine (PMID: 2621422) Feces (PMID: 22664055 ) Cellular substructure Extracellular (HMDB: HMDB0000946)

Source Food

Associated disorders diseases: Cystic fibrosis Smith JL, Lewindon PJ, Hoskins AC, Pereira TN, Setchell KD, O'Connell NC, Shepherd RW, Ramm GA: Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis. Hepatology. 2004 Jun;39(6):1673-82. [PubMed:15185309 ] Colorectal cancer Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803] Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [] Primary biliary cirrhosis Batta AK, Arora R, Salen G, Tint GS, Eskreis D, Katz S: Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment. J Lipid Res. 1989 Dec;30(12):1953-62. [PubMed:2621422 ]

KEGG compound ID: C07880

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C07880

HMDB link: https://hmdb.ca/metabolites/HMDB0000946

PubChem CID: 31401

PubChem CID link: https://pubchem.ncbi.nlm.nih.gov/compound/31401