Biomarker: 4-methoxy-E2 (4MeO-E2)

Histology type: endometrial carcinoma

Country: Canada

Region: Québec

Followed up time :

Cohort statistics: Mean (SD)

Description: Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Sample type : serum

Sample method: mass spectrometry-based assays,

Expression pattern : preoperative=13.6 (2.5-51.5)

Cohort age: 65.1 ± 8.9

Status: Detected and Quantified

HMDB ID: HMDB0000405

Secondary accession numbers: HMDB00405

Common name: 2-Methoxyestradiol

Description: 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumours need in order to grow (angiogenesis). It is derived from estrogen, although it binds poorly to known estrogen receptors, and belongs to the family of drugs called angiogenesis inhibitors. It has undergone phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. 2ME2 also acts as a vasodilator.

Chemical formula: C19H26O3

Chemical taxonomy description: Belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Estrane steroids

Direct parent: Estrogens and derivatives

Alternative parents: 3-hydroxysteroids Steroids carrying a hydroxyl group at the 3-position of the steroid backbone. 17-hydroxysteroids Phenanthrenes and derivatives Tetralins Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Cyclic alcohols and derivatives Hydrocarbon derivatives

Substituents: Estrogen-skeleton 3-hydroxysteroid 17-hydroxysteroid Hydroxysteroid Phenanthrene Tetralin Anisole 1-hydroxy-2-unsubstituted benzenoid Alkyl aryl ether Benzenoid Cyclic alcohol Secondary alcohol Ether Organic oxygen compound Organooxygen compound Hydrocarbon derivative Alcohol Aromatic homopolycyclic compound

Molecular framework: Aromatic homopolycyclic compounds

Physiological effect:

Disposition: Biological location Cellular substructure: Extracellular Non-excretory biofluid: Blood Excreta: Urine Tissue: Connective tissue,Adipose tissue Organ:Prostate

Source Animal foods,

Associated disorders diseases: Ovarian cancer [PubMed:15818726 ]

KEGG compound ID: C05302

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C05302

HMDB link: https://hmdb.ca/metabolites/HMDB0000405