Biomarker: estrone-sulfate (E1-S)

Histology type: endometrial carcinoma

Country: Canada

Region: Québec

Followed up time :

Cohort statistics: Mean (SD)

Description: Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Sample type : serum

Sample method: mass spectrometry-based assays,

Expression pattern : preoperative >0.31ng/mL

Cohort age: 65.1 ± 8.9

Status: Detected and Quantified

HMDB ID: HMDB0001425

Secondary accession numbers: HMDB01425

Common name: Estrone sulfate

Description: Estrone sulfate is a sulfated estrone derivative. Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). Estrone Sulfate (E1S) is the most abundant circulating estrogen in non-pregnant women as well as normal men. Estrone is primarily synthesized from estrone sulfate. Estrone is an estrogenic hormone secreted by the ovaries and adipose tissues. Estrone is one of the three estrogens found in humans. The other two are estriol and estradiol. Estrone is the least prevalent of the three. Estradiol plays a critical role on reproductive and sexual functioning in women and it also affects other organs including the bones. Estriol is an estrogen that is prevalent primarily during pregnancy.

Chemical formula: C18H22O5S

Chemical taxonomy description: Belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Sulfated steroids

Direct parent: Sulfated steroids

Alternative parents: Estrane steroids 17-oxosteroids Phenanthrenes and derivatives Tetralins Arylsulfates Sulfuric acid monoesters Ketones Organic oxides Hydrocarbon derivatives

Substituents: Sulfated steroid skeleton Estrane-skeleton 17-oxosteroid Oxosteroid Phenanthrene Arylsulfate Tetralin Benzenoid Sulfuric acid ester Sulfuric acid monoester Sulfate-ester Organic sulfuric acid or derivatives Ketone Hydrocarbon derivative Organic oxide Organooxygen compound Carbonyl group Organic oxygen compound Aromatic homopolycyclic compound

Molecular framework: Aromatic homopolycyclic compounds

Physiological effect: Adverse health effect A health condition or observation associated with a stimuli or with a biological activity of a chemical Genetic disorder Inborn errors of metabolism Sulfite oxidase deficiency (PMID: 22800120 , PMID: 32966057 , PMID: 18953024 , +11 More )

Disposition: Biological location Cellular substructure: Cytoplasm Organelle: Endoplasmic reticulum Extracellular Non-excretory biofluid: Blood Excreta:Urine Tissue:Epithelium,Epidermis Organ: Intestine,Kidney, Liver, Ovary, Placenta Cell:Hematocyte, Platelet

Source Animal foods,Milk and milk products

Associated disorders diseases: #Obesity [PubMed:2401584 ] # X-linked ichthyosis[PubMed:3864567 ]

KEGG compound ID: C02538

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C02538

Process: Metabolic pathway Androgen and estrogen metabolism Estrone metabolism Sulfate/sulfite metabolism

HMDB link: https://hmdb.ca/metabolites/HMDB0001425