Pubmed Biomarker P-value Description
33832498 mesothelin p=0.02 More patients with co-expression of mesothelin and CA125 had positive lymphovascular invasion
28277313 androgen receptor (AR) p=0.041 AR expression was correlated with absence of lymphovascular invasion
27648714 L1CAM L1CAM positivity was associated with lymphovascular space invasion.(OR=2.8)
26985869 MIF p=0.012 MIF protein expression was significantly lower in endometrial carcinoma with no lymphovascular invasion
26985869 c-erbB-2 p=0.012 C-erbB-2 expression was significantly lower in endometrial carcinoma with no lymphovascular invasion
26985869 MIF p=0.012 MIF mRNA overexpression appeared to correlate with lower aggressiveness: It was significantly associated with no lymphovascular invasion
26985869 c-erbB-2 p=0.024 The analysis demonstrated that the levels of c-erbB-2 mRNA were higher in lymphovascular invasion, compared with no lymphovascular invasion.（2.352±1.389 vs. 4.067±1.284）
26763250 POLE exonuclease domain mutations (EDM) p<0.05 LVSI was present in 49% of POLE mutated carcinomas, yet out of 262 patients who had a lymph node dissection, not one patient with a POLE EDM was node positive
26647729 CCNE1 p=0.0258 CCNE1 amplification were were correlated with lymphovascular space invasion
26608413 CD44 p=0.019 CD44 expression decreased were correlated with lymph-vascular space invasion (LVSI)
25355598 HABP1 p=0.01 High HABP1 expression was significantly associated with lymphovascular space invasion
33235117 TWIST1 p=.02 Increased TWIST1 expression was significantly associated with LVSI
24972085 Yes-associated protein (YAP) p=0.0008 Increased nuclear YAP expression was significantly associated with lympho-vascular space invasion
24659664 CA 125 p=0.01 Elevated preoperative serum CA 125 levels (mean 31.5 U/ml) in postmenopausal women were significantly correlated with the presence of lympho-vascular space involvement (LVSI)
24590269 TNFAIP8 p=0.011 An association was observed between TNFAIP8 overexpression and lymphovascular space invasion
22015044 Synuclein-γ (SNCG) protein p<0.001 There was a strong association between SNCG+ and presence of LVI
20715109 HAI-2 p=0.003 The expression of HAI-2 was found to have a statistically significant association with LVS involvement.
19823058 FAK p=0.003 Increased expression of FAK correlated with lymphatic vascular space invasion
17527071 MSI p=0.008 The MSI-high phenotype was related with the presence of lymphovascular invasion
17065588 versican p=0.014 Epithelial versican expression was significantly higher in patients with lymph-vascular space involvement
16445666 cyclin H The expression of cyclin H was correlated with lymphvascular space invasion
16080017 skp2 The high level of skp2 expression was significantly correlated with lymph-vascular space involvement.
33156532 HE4 p=0.001 A statistically significant association was found between the preoperative HE4 value and lymphovascular space invasion
11161861 VEGF p=0.001 Higher cytosol VEGF concentrations were noted in tumors with lymphovascular emboli (917 versus 102 pg/mg）
11161861 MVD p=0.009 Higher MVD were noted in tumors with lymphovascular emboli.(94.4 +/- 33.2 versus 62.4 +/- 40.7)
10376438 p53 p<0.05 The difference between lymphovascular space invasion and no lymphovascular invasion and p53 positivity was statistically significant
9038731 CA 72-4 p<0.05 Serum CA72-4 positivity was correlated with lymphovascular space involvement,
8697392 desmoplakin II The expression was lower in cases of lymph node metastasis than in negative cases and was lower in the cases with > one-half myometrial invasion than in cases with < one-half myometrial invasion.
8664123 cathepsin D The expression was lower in cases of lymph node metastasis than in negative cases and was lower in the cases with > one-half myometrial invasion than in cases with < one-half myometrial invasion.
36396713 CA125 Patients with CA125 ≥ 175U/ml had significantly increased risk of +LVSI, with maximum increase in risk of 39% (1.39-fold risk) at 222U/ml.
36251972 p53 P <0.001 Abnormal p53 IHC expression was expressed in 33.3% of the cases and significantly associated with the tumor grade, myometrial invasion (MI), lymphovascular invasion (LVSI), nodal metastasis, and FIGO stage, and the advanced European Society for Medical Oncology (ESMO) risk groups
36251972 Pirh2 P =0.011 High IHC Pirh2 expression was noted in 58.3% of the cases, and significantly associated with LVSI
36251972 L1CAM P =0.003 Positive L1CAM immunoexpression was noted in 26.7% and was significantly associated with LVSI
30557309 L1CAM p=0.008 L1CAM is highly associated with LVSI
35866777 KRT15 P = .010 Elevated KRT15 protein expression was correlated with the occurrence of lymphovascular invasion.
36521837 (ERα + PR)/(Ki67 + P53) P < .05 This study showed that CA125, grade, LVSI, ERα, PR, P53, Ki67 have statistical significance.
29895385 The signal intensity (SI) p<0.001 Tumours with qualitative higher signal than that of normal myometrium on the late T1WI DCE image sequences were more likely to have lymphovascular space invasion
29353001 mPRβ p = 0.0073 The stratification analysis revealed significantly lower scores for mPRβ in the samples from patients with lymphovascular invasion
29114696 cancer antigen 15-3 levels p<0.05 Serum cancer antigen 15-3 levels were significantly higher in patients with lymphovascular space invasion
29114696 cancer antigen 15-3 levels p=0.01 The mean serum CA15-3 levels were significantly higher in patients with LVSI compared to patients without LVSI.（29.0±29.4 [4.0-153.0] IU/mL vs 19.3±8.3 [4.0–41.0] IU/mL）
28401338 HE4 p=0.04 Serum HE4 concentration is significantly associated with extensive lymph vascular space invasion

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