Pubmed Biomarker P-value Description
34339705 TMEFF2 p=0.023 TMEFF2 expression was associated with lymph node metastases
32630554 MSX1 p=0.031 A significant stronger expression of MSX1 was found in tumor material of patients with no involvement of lymph nodes
36721236 SLERT P = 0.018 SLERT was significantly correlated with lymph node metastasis
34282107 TAM P=0.005 The counts of margin TAMs was significantly correlated with lymph node metastases.
32433831 COX-2 p<.001 The affected from the disease lymph nodes cases showed positive expression of COX-2 (41.2%) than the non-affected lymph nodes (13.4%)
30684972 RRBP1 p=0.021 High levels of expression of RRBP1 were strongly correlated with lymph node metastasis
30645608 GDF-15 High plasma level GDF-15 predicts Lymph node metastases（OR = 2.64; 95% CI 1.52–4.61）
30556848 LncRNA FER1L4 p=0.010 Low expression of FER1L4 was significantly correlated with lymph node metastasis
30539847 PD-L1 p=0.027 PD-L1 expression was significantly associated with lymph node metastasis
30539847 HIF-1α p=0.046 HIF-1α expression was significantly associated with lymph node metastasis
30508211 preoperative CA125 p<0.0001 in older patients (> 50 years) with lymphadenectomy, preoperative CA125 level was predictable for LNM and area under the curve value was 0.695.((95% confidence interval: 0.602–0.787）)
30508211 preoperative CA125 p<0.0001 LNM was observed in 13% and 35% of the patients with a CA125 level of ≤ 16 IU/mL and > 16 IU/mL, respectively
30428472 CK19 p<0.01 CK19 mRNA expression was higher in pathologically positive LN than in pathologically negative LN
34339705 SMOC-2 p=0.023 SMOC-2 high expression was positively correlated with lymph node metastases
29984790 MACC1/c-Myc p<0.05 MACC1/c-Myc expression was correlated with lymph node metastasis
29848072 miR-29b p<0.05 miR-29b expression in the peripheral blood was correlated with LNM
29526558 TRIM44 p<0.05 TRIM44 overexpression was associated with lymph node metastasis
29516012 visfatin p=0.01 Significantly higher concentrations of visfatin have been observed in patients with lymph node metastases
29516012 visfatin p=0.01 Significantly higher concentrations of visfatin have been observed in patients with lymph node metastases
29114696 cancer antigen 15-3 levels p<0.05 Serum cancer antigen 15-3 levels were significantly higher in patients with positive lymph node involvement
29114696 cancer antigen 15-3 levels p=0.002 The mean serum CA15-3 levels were significantly higher in patients with LNI compared to patients without LNI.（36.5±42.9 [10.7-153.0] IU/mL vs 19.9±8.8 [4.0-44.0] IU/mL）
28980703 IRAK1 p<0.05 Fisher’s exact test indicated that IRAK1 expression level was significantly correlated with lymph node metastasis
28751757 L1CAM p=0.002 Expression of L1CAM were independent predictor of lymph node metastases
28751757 L1CAM p<0.001 Patients with high L1CAM expression in curettage specimen had significantly higher occurrence of lymph node metastases compared with patients with low expression of L1CAM in the whole patient population (33% vs 10% respectively)
34331128 microRNA-21 p=0.018 High miR-21 expression in cance cell was associated with lymph node metastasis ( positive VS negative )
28751757 L1CAM p=0.002 When adjusting for curettage histology and preoperative ER/PR loss in a multivariate model, high expression of L1CAM predicted lymph node metastases with adjusted（OR 2.51 ；95% CI 1.41–4.64)
28751757 L1CAM p=0.048 when correcting for curettage histology in a multivariate model, sL1CAM level in plasma was a predictor of lymph node metastases with OR 2.25 (95% CI 1.01–5.02).
28624692 CA125 p<0.001 We observed significantly higher CA125 concentrations in patients with higher levels of clinical stages when compared to patients in patients with metastases to the regional lymph nodes compared to patients without metastases
28453461 SerpinE2 p=0.036 high SerpinE2 expression was correlated with lymph node metastasis
28277313 androgen receptor (AR) p=0.048 AR expression was correlated with decreased LN involvement
27648714 L1CAM L1CAM positivity was associated with lymph node involvement（OR= 2.9）
27540975 UCA1 p=0.008 High UCA1 expression was observed to be closely correlated with lymph node metastasis
27340318 IL-33 p=0.029 Serum IL-33 was close to the disease process: existence of node metastases
26985869 MIF p=0.01 MIF protein had a higher expression in tumors with no lymph node metastasis.（χ2=6.556）
26985869 c-erbB-2 p=0.013 C-erbB-2 protein expression was higher in tumors at with lymph node metastasis.（χ2=6.149）
34109467 HE4 p=0.017 Serum HE4 levels was significantly associated with lymph node metastasis
26957478 Estrogen receptor-alpha ERα was a strong predictor of lymph node involvement.（RR: 2.37, 95% CI: 1.12-5.02）
26678075 sialyl Tn (STN) p=0.006 Elevated serum STN levels were associated with lymph node metastasis
26539494 HE4 p=0.002 The strongly positive expression rate of HE4 in patients with lymph node metastasis (73.33%) was significantly higher than that in patients without lymph node metastasis (41.40%)
26362938 ANXA2 p<0.05 The high expression rate of ANXA2 in the lymph node metastasis group was 94.7 % (18/19), which was significantly higher than the negative lymph node metastasis group (58.0 % [29/50]
26362938 HE4 p<0.05 The high expression rate of HE4 in the positive lymph node metastasis group was 68.4 % (13/19), which was significantly higher than the negative lymph node metastasis group (36.0 % [18/50]
26260911 Metabolic syndrome p=0.014 MS was closely related to lymphatic metastasis
26111272 TILs Multivariate analysis identified a low number of TILs (<10), positive lymph node involvement
26045311 MTV p=0.001 Optimal cutoffs for MTV in predicting the presence of lymph node metastases (30 mL) (OR: 16.5 (CI, 3.4–80.3)
26045311 TLG p<0.025 TLG were independently predicted lymph node metastases after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
26045311 TLG p<0.025 TLG were independently predicted lymph node metastases after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
33635467 BMP-10 p=0.009 BMP-10 expression was significantly correlated with lymph node metastasis
26045311 SUVmax (standardized uptake value) p<0.025 SUVmax were independently predicted lymph node metastasesafter adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies.
26045311 MTV ROC curves showed that MTV had the highest areas under the curve: 0.86 in predicting lymph node metastases.（(ROC=0.86）
25964114 CA125 ROC curve analysis results showed the CA125 serum level of 25 U/mL was the best cutoff to predict the lymph node metastasis. It was with 78% of sensitivity, 78% of specificity, 77.6% of false positive rate, 2.3% of false negative rate in all patients.
25951350 Enolase-1 p=0.005 The expression level of ENO1 was positively correlated with lymph node status
25544793 ZEB1 p<0.001 Between ZEB1 expression in patients with lymph node metastasis (5.31 ± 3.15) and without lymph node metastasis (3.37 ± 3.02), a significant difference has been found
25544793 ZEB1 ZEB1 expression greater than 4.92 demonstrated a sensitivity and specificity of 57.8% and 74.1%, respectively, for lymph node metastasis（AUC = 0.657;95% CI, 0.541–0.774）
25355598 HABP1 p=0.015 High HABP1 expression was significantly associated with lymph node metastasis
24692842 HDGF p=0.036 High HDGF protein expression was significantly associated with lymph node metastasis
24692842 HDGF p=0.037 High HDGF protein expression was significantly associated with without lymph node metastasis
24590269 TNFAIP8 p<0.001 An association was observed between TNFAIP8 overexpression and lymph node metastasis
33235117 TWIST1 p=.001 Increased TWIST1 expression was significantly associated with LNM
24067230 Pin1 Pin1 expression was negatively correlated with lymph node metastasis
23932335 Double negative hormone receptor ER/PR loss independently predicted lymph node metastasis adjusted for preoperative curettage histology.(OR=2.0, 95% confidence interval :1.1-3.7)
22617129 bFGF p=0.002 Tumour bFGF was significantly associated with positive lymph-node involvement
22008707 ADCmin p=0.027 There were significant correlations between the ADCmin of the primary tumor and lymph node metastasis
21616994 GDF-15 p≤0.001 High plasma GDF-15 was significantly associated with lymph node metastases
21242118 Stathmin Stathmin expressions in curettage specimens was the strongest and the only independent predictor of lymph node metastasis,with a sensitivity = 0.47, specificity = 0.66, positive predictive value (PPV) = 0.17, and negative predictive value (NPV) = 0.89.
21242118 Stathmin Analyzing Stathmin expressions in curettage specimens in the high-risk curettage the respective values are 1.42 (95% CI: 0.57–3.53), sensitivity = 0.67, specificity = 0.41, PPV = 0.27, and NPV = 0.79.
21176560 Hsa-miR-155 p<0.01 The expressions of hsa-miR-155 were (5.5 ± 0.5) and (1.9 ± 0.2) times between lymph node metastasis and without lymph node metastasis in endometrial cancer, in which there were significant difference
20715109 HAI-2 p=0.023 The expression of HAI-2 was found to have a statistically significant association with clinicopathological parameters such as lymph node metastasis .
18422745 Midkine (MK) p=0.008 Patients with positive lymph node metastasis or recurrence, or cancer death, had a higher serum MK level
33156532 HE4 p=0.008 A statistically significant association was found between the preoperative HE4 value and node involvement
17504383 beta-catenin p=0.008 Positive beta-catenin expression was significantly associated with negative lymph nodes
17504383 p53 p=0.001 Positive staining of p53 was significantly correlated with lymph node metastases.
17260229 CA-125 p<0.001 Elevated serum CA-125 levels were significantly correlated with lymph node metastases
17139987 CD24 p=0.002 Membranous staining of CD24 was significantly associated with nodal status
17139987 CD24 p=0.000 Cytoplasmic staining of CD24 was significantly associated with nodal status
17065588 versican p=0.012 Stromal versican expression was significantly higher in lymph node metastasis
17065588 versican p=0.014 Epithelial versican expression was significantly higher in patients with lymph node metastasis
16919631 Nm23 p=0.01 Slides from 15 patients (79%) with lymph node involvement and 22 patients (88%) without lymph node involvement were found to be positive for Nm23
16919631 Nm23 p=0.02 Nm23 expression was found to be significantly related to lower rates of lymph node metastasis and longer survival
16681769 ERRalpha and ERRgamma p=0.021 A negative correlation was observed between expression of ERRgamma mRNA and nodal metastasis
32769331 TROP2 p≤0.05 High overexpression of TROP2 was seen in pelvic-lymph-node metastasis.
16080017 skp2 The high level of skp2 expression was significantly correlated with the presence of lymph node metastasis
16014121 c-FLIP p<0.05 Multivariate analysis of variance also confirmed the association of c-FLIP with lymph node metastasis
16014121 c-FLIP p<0.01 The expression levels of c-FLIP protein were significantly higher in endometrial carcinomas with lymph node metastasis than in those without lymph node metastasis.Multivariate analysis of variance confirmed that the expression levels of c-FLIP were indeed associated with lymph node metastasis .
15218296 placental leucine aminopeptidase p<0.01 There was a positive correlation between the expression of P-LAP and lymph node involvement
15025952 cFLIP p<0.01 cFLIP expression was also significantly associated with positive lymph node metastasis of endometrial adenocarcinomas.
12819391 endoglin (CD105) p<0.01 Only endoglin counts correlated significantly with the presence of lymph nodes metastases
12747468 CD44 variant 6 CD44v3-expression correlated significantly with lymph node metastasis.
11161861 VEGF p<0.001 Higher cytosol VEGF concentrations were noted in tumors with lymph node metastasis（1032 versus 95 pg/mg）.
11161861 MVD p<0.001 Higher MVD were noted in tumors with lymph node metastasis（116.5 +/- 30.8 versus 56.7 +/- 33.3）.
10053107 PR p=0.001 Lymph node metastases from endometrial carcinoma were statistically correlated with negative PR immunohistochemistry
32769331 TROP2 High overexpression of TROP2 was seen in pelvic-lymph-node metastasis
10053107 PR p=0.0001 On multivariate analysis, negative PR was significant prognostic variables for lymph node metastases
9570981 GST-pi Multivariate analysis revealed that GST-pi expression correlated independently with paraaortic lymph node (PAN) metastasis
9570981 c-Jun Multivariate analysis revealed that c-Jun expression was independently related to pelvic lymph node (PLN) and PAN metastasis.
9038731 CA 72-4 p<0.05 Serum CA72-4 positivity was correlated with para-aortic lymph node metastasis.
8697392 desmoplakin I The expression was lower in cases of lymph node metastasis than in negative cases
8088605 CA 125 p=0.022 CA 125 positivity (> 65 U/ml) was 22% in patients without metastatic lymph node involvement, compared to 58% of cases with histologically positive lymph nodes
8088605 CA 125 p=0.022 CA 125 positivity (> 65 U/ml) was 22% in patients without metastatic lymph node involvement, compared to 58% of cases with histologically positive lymph nodes
27898420 BANCR p=0.025 The level of BANCR expression was correlated with lymph node metastasis
36123915 APOE P < .05 The expression level of APOE in endometrial cancer was correlated with histological grade, lymph node metastasis, and FIGO stage.
36123915 APOE P < .05 Lymph node metastasis and APOE were independent risk factors affecting the prognosis and survival of patients.

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