Biomarker: SMOC-2

Biomarker subtype: gene

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Egypt

Region: Zagazig

Study type: prospective cohort study

Followed up time : 50 months (range from 25 to 60).

Cohort age: 78;42

Sample type : tissue

Clinical method: immunohistochemistry

Expression pattern : highly expression(>5)

Expression elevation: Staining intensity was scored as 0, 1, 2, and 3, The percentage of stained cells observed in the whole section, < 5%, 5–25%, 26–50%, 51–75%, and > 75%, was scored as 0, 1, 2, 3, and 4, respectively. The above two scores were multiplied to obtain the final score as follows: 0 to 2 (? ); 3 to 4, (+); 5 to 8 (++); and 9 to 12, (+++). We considered values below 5 as low expression and values equal to and larger than 5 as high

Statictics: cutoff<55;cutoff>55

Cohort age: 78;42

Description: SMOC-2 was highly expressed in EC and were associated with a shortened survival rate, dismal outcome, and poor prognosis in EC patients

Approved symbol: SMOC2

Approved name: SPARC related modular calcium binding 2

Locus type: gene with protein product

HGNC ID: HGNC:20323

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20323

Symbol status: Approved

Alias symbols: SMAP2

Alternative gene group name: secreted protein acidic and rich in cysteine family

Subgroup: EF-hand domain containing

OMIM: 607223

Omim link: https://www.omim.org/entry/607223

NCBI name: 64094

NCBI link: https://www.ncbi.nlm.nih.gov/gene/64094

Summary: This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Expression: Broad expression in endometrium (RPKM 68.7), gall bladder (RPKM 54.9) and 18 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/64094#gene-expression