Basic information
Biomarker: Human kallikrein 6 (hK6)
Biomarker subtype: gene
Clinical application: prognosis(unfavorable)
Histology type: rare type
Cohort characteristics
Country: USA
Region: Arkansas
Study type: Comparative Study
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 14 | USPC | 3 | endometrioid carcinoma | 3 | ovarian serous papillary carcinoma | 5 | cervical cancers | 3 |
Sample information
Sample type : serum
Clinical method: ELISA,real-time PCR
Expression pattern : expression
Disease information
Related information
Description: hK6 is highly expressed in USPC and is released in the plasma and serum of USPC patients. hK6 may represent a novel biomarker for USPC for monitoring early disease recurrence and response to therapy.
Approved symbol: KLK6
Approved name: kallikrein related peptidase 6
Locus type: gene with protein product
HGNC ID: HGNC:6367
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6367
Symbol status: Approved
Previous symbols: PRSS9 PRSS18
Alias symbols: Bssp Klk7 neurosin
OMIM: 602652
Omim link: https://www.omim.org/entry/602652
NCBI name: 5653
NCBI link: http://view.ncbi.nlm.nih.gov/gene/5653
Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Expression: Biased expression in esophagus (RPKM 23.8), brain (RPKM 23.7) and 4 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5653#gene-expression
PDB ID: Q92876
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q92876)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
