Basic information
Biomarker: ERRalpha
Biomarker subtype: mRNA
Clinical application: prognosis
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: China
Region: Beijing
Study type: Comparative Study
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 35 | EC | 35 | normal endometrium |
Sample information
Sample type : tissue
Clinical method: RT-PCR/immunohistochemistry
Expression pattern : expression;amplification
Expression elevation: Immunoreactivities of ERRs were classified into four groups: 2, ,10% of positive cells; 1, 10–25% of positive cells; 11, 25–50% of positive cells; and 111, .50% of positive cells.
Disease information
Related information
Description: Results suggested that ERRalpha might participate in the tumorigenesis of endometrial adenocarcinoma. ERRalpha is promising to be new prognostic factors in endometrial adenocarcinoma.
Approved symbol: ESRRA
Approved name: estrogen related receptor alpha
Locus type: gene with protein product
HGNC ID: HGNC:3471
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3471
Symbol status: Approved
Previous symbols: ESRL1
Alias symbols: ERR1 ERRalpha NR3B1 ERRa
Alternative gene group name: Nuclear receptor subfamily 3 group B
Subgroup: Nuclear hormone receptors (NR)
OMIM: 601998
Omim link: https://www.omim.org/entry/601998
NCBI name: 2101
NCBI link: https://www.ncbi.nlm.nih.gov/gene/2101
Summary: The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]
Expression: Ubiquitous expression in duodenum (RPKM 26.2), kidney (RPKM 21.8) and 24 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/2101#gene-expression
PDB ID: P11474
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P11474)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: TF
Term ID: TF:M03945_1
Term name: Factor: CENPB; motif: CCCGCNTNNNRCGAA; match class: 1
