Basic information
Biomarker: TADG-14
Biomarker subtype: gene
Clinical application: diagnosis
Histology type: endometrial carcinoma
Stage: early stage in menopausal women.
Cohort characteristics
Country: Japan
Region: Fukuyama
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 81 | EC | 44 | normal endometria | 37 |
Sample information
Sample type : tissue
Clinical method: RT-PCR
Expression pattern : TADG-14/KLK8 expression
Disease information
Related information
Description: We suggest that expression of TADG-14/KLK8may be regulated by sex steroid hormones in endometria. Our results indicate that elevated TADG-14/KLK8 expression is an early event in endometrial carcinogenesis, and may potentially serve as a useful early biomarker for the detection of endometrial carcinomas in menopausal women.
Approved symbol: KLK8
Approved name: kallikrein related peptidase 8
Locus type: gene with protein product
HGNC ID: HGNC:6369
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6369
Symbol status: Approved
Previous symbols: PRSS19
Alias symbols: HNP TADG14 neuropsin ovasin
Alternative gene group name: $ "Serine peptidases", "Serine endopeptidases", "Proteases, serine"
OMIM: 605644
Omim link: https://www.omim.org/entry/605644
NCBI name: 11202
NCBI link: https://www.ncbi.nlm.nih.gov/gene/11202
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression: Biased expression in skin (RPKM 32.0) and esophagus (RPKM 29.8)
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/11202#gene-expression
PDB ID: O60259
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(O60259)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
