Basic information
Biomarker: PRA
Biomarker subtype: gene
Clinical application: prognosis(risk factor in disease-free survival of the patients)
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: Japan
Region: Sendai
Study type: retrospective study
Followed up time : 60 months (range, 2–148 months)
Cohort age: 22;81
Protocol age: 15;26
Control age: 7;45
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 103 | endometrioid endometrial carcinoma | 103 |
Sample information
Sample type : tissue
Clinical method: real-time RT-PCR
Expression pattern : loss or absence
Disease information
Statictics: cutoff<50;cutoff>50
Cohort age: 22;81
Protocol age: 15;26
Control age: 7;45
Related information
Description: The results of our study demonstrated that loss or absence of PR isoform expression determined by immunohistochemistry could become an important prognostic indicator in patients with endometrioid endometrial carcinoma.
Approved symbol: PGR
Approved name: progesterone receptor
Locus type: gene with protein product
HGNC ID: HGNC:8910
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8910
Symbol status: Approved
Alias symbols: PR NR3C3
Alternative gene group name: 3-Ketosteroid receptors
Subgroup: Nuclear hormone receptors (NR)
OMIM: 607311
Omim link: https://www.omim.org/entry/607311
NCBI name: 5241
NCBI link: https://www.ncbi.nlm.nih.gov/gene/5241
Summary: This?gene?encodes a member of the steroid receptor superfamily. The encoded?protein?mediates the physiological effects of?progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This?gene?uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both?protein?coding and non-protein?coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Expression: Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5)
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5241#gene-expression
PDB ID: P06401
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P06401)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
