Biomarker: EphB4

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Japan

Region: Gifu City

Followed up time : 60-month

Sample type : tissue

Clinical method: real-time RT-PCR

Expression pattern : Overexpression

Description: EphrinB2 and EphB4 were overexpressed during the tumor advancement as dedifferentiation and myometrial invasion. Therefore, ephrinB2/EphB4 might work on tumor advancement and may be recognized as a novel prognostic indicator for uterine endometrial cancers.

Approved symbol: EPHB4

Approved name: EPH receptor B4

Locus type: gene with protein product

HGNC ID: HGNC:3395

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3395

Symbol status: Approved

Previous symbols: HTK

Alias symbols: Tyro11

Alternative gene group name: "SAM domain containing"$"Ephrin receptors"

Subgroup: $ "Fibronectin type III domain containing", "Receptor tyrosine kinases"

OMIM: 600011

Omim link: https://www.omim.org/entry/600011

NCBI name: 2050

NCBI link: https://www.ncbi.nlm.nih.gov/gene/2050

Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in placenta (RPKM 28.2), endometrium (RPKM 22.9) and 24 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/2050#gene-expression

PDB ID: P54760

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P54760)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D