Biomarker: Prostate-specific membrane antigen

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrioid endometrial carcinoma

Country: USA

Region: NY

Followed up time : 17 (0-90)

Cohort age: 66;30-87

Sample type : tissue

Clinical method: RT-PCR

Expression pattern : loss expression

Validation in cell line : urologic and gynecologic cell lines

Validation in cell method : RT-PCR,Methylation-Specific PCR,

Statictics: Mean ;Range

Cohort age: 66;30-87

Description: Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma.

Approved symbol: FOLH1

Approved name: folate hydrolase 1

Locus type: gene with protein product

HGNC ID: HGNC:3788

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3788

Symbol status: Approved

Previous symbols: folate hydrolase (prostate-specific membrane antigen) 1

Alias symbols: FOLH

OMIM: 600934

Omim link: https://www.omim.org/entry/600934

NCBI name: 2346

NCBI link: https://www.ncbi.nlm.nih.gov/gene/2346

Summary: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Expression: Biased expression in duodenum (RPKM 94.9), prostate (RPKM 43.3) and 6 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/2346#gene-expression

PDB ID: Q04609

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q04609)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

MF term ID: GO:1904492|GO:1904493

MF term name: Ac-Asp-Glu binding | tetrahydrofolyl-poly(glutamate) polymer binding

Source description: KEGG | TF

Term ID: KEGG:04977 | TF:M06350

Term name: Vitamin digestion and absorption | Factor: ZNF449; motif: NTGGGCGTAGGA