Biomarker: BMI-1

Biomarker subtype: gene

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Norway

Region: Bergen

Study type: prospective study

Followed up time : 9 years (range 5–15 years)

Sample type : tissue

Clinical method: qPCR

Expression pattern : Loss expression

Expression elevation: A staining index (SI) was calculated as a product of staining intensity (0–3) and area of positive tumour cell nuclei (1=<10%, 2=10–50%, 3=>50%).Evaluation of the cases was carried out blinded for patient characteristics and outcome. In subsequent statistical analyses, the cut-off was based on the median value for the SI, after considering the frequency distribution curve and the size of subgroups.

Description: Loss of BMI-1 seems to be associated with an aggressive phenotype in endometrial carcinomas.

Expression figure legend: Representative immunohistochemical staining for TFF3

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528153/figure/fig2/

Approved symbol: BMI1

Approved name: BMI1 proto-oncogene, polycomb ring finger

Locus type: gene with protein product

HGNC ID: HGNC:1066

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1066

Symbol status: Approved

Previous symbols: polycomb group ring finger 4 B lymphoma Mo-MLV insertion region 1 homolog (mouse)

Alias symbols: RNF51

Alternative gene group name: | "zf-RING", "Zinc fingers, RING (C3HC4)-type"

Subgroup: Zinc fingers

OMIM: 164831

Omim link: https://www.omim.org/entry/164831

NCBI name: 648

NCBI link: https://www.ncbi.nlm.nih.gov/gene/648

Summary: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

Expression: Ubiquitous expression in testis (RPKM 21.4), endometrium (RPKM 20.1) and 25 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/648#gene-expression

PDB ID: P35226

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P35226)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D