Basic information
Biomarker: DNA ploidy
Biomarker subtype: DNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Norway
Region: Bergen
Study type: prospective Comparative Study
Followed up time : 18.5 years (range, 13.2–23.2)
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 363 | routine diagnostic serie | 262 | previous research series | 101 |
Sample information
Sample type : tissue
Clinical method: image cytometry
Expression pattern : aneuploid
Expression elevation: When only 1 cell population could be identified, the tumor was classified as DNA diploid. In cases with 2 cell populations, the DNA index (DI) was calculated. Cases with DI greater than 1.0 were classified as DNA aneuploid. Because there were no DNA tetraploid or polyploid cases in our study population, we used the term DNA diploid vs aneuploid to desc
Disease information
Related information
Description: DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.
Survival figure legend: (a) Local Disease Free Survival, (b) Disease Free Survival and (c) Cancer Specific Survival according to tumor microsatellite status in patients with primary endometrioid endometrial cancer. MSI, microsatellite instability; MSS microsatellite stability.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796581/figure/F1/?report=objectonly
Detailed Description: Ploidy is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Sets of chromosomes refer to the number of maternal and paternal chromosome copies, respectively, in each homologous chromosome pair, which chromosomes naturally exist as. Somatic cells, tissues, and individual organisms can be described according to the number of sets of chromosomes present (the "ploidy level"): monoploid (1 set), diploid (2 sets), triploid (3 sets), tetraploid (4 sets), pentaploid (5 sets), hexaploid (6 sets), heptaploid[doi:10.1007/bf00119108] or septaploid[3] (7 sets), etc. The generic term polyploid is often used to describe cells with three or more chromosome sets.[doi:10.1007/978-3-642-96327-8][Darlington, C. D. (Cyril Dean) (1937). Recent advances in cytology. Philadelphia: P. Blakiston's son & co. p. 60.]
