Basic information
Biomarker: YT521
Biomarker subtype: mRNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Germany
Region: Freiburg
Followed up time : median follow-up time was 17 months (mean, 26 months; range, 1-110 months)
Cohort age: 55;75
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 130 | EC | 130 |
Sample information
Sample type : tissue
Clinical method: Real-time reverse transcription-polymerase chain reaction
Expression pattern : exon 6- skipping mRNA splicing isoform of YT521 (high level )
Expression elevation: The relative quantification of the 75th percentile or higher of all analyzed samples was defined as high level, whereas that of less than the 75th percentile of all analyzed samples was defined as low level
Disease information
Statictics: cutoff<65;cutoff>65
Cohort age: 55;75
Related information
Description: We identified YT521 as a potential new independent prognostic factor for patients with EC: the lack of YT521 protein in tumor cells was highly predictive for a poor overall and disease-specific survival and independent from the histological subtypes.
Approved symbol: YTHDC1
Approved name: YTH domain containing 1
Locus type: gene with protein product
HGNC ID: HGNC:30626
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30626
Symbol status: Approved
Alias symbols: YT521 KIAA1966 YT521-B
OMIM: 617283
Omim link: https://www.omim.org/entry/617283
NCBI name: 91746
NCBI link: https://www.ncbi.nlm.nih.gov/gene/91746
Summary: Enables N6-methyladenosine-containing RNA binding activity. Involved in mRNA export from nucleus; mRNA splice site selection; and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 22.7), ovary (RPKM 15.2) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/91746#gene-expression
PDB ID: Q96MU7
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q96MU7)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: TF
Term ID: TF:M06680
Term name: Factor: ZNF251; motif: NGGGWAATCGGA
