Biomarker: survivin

Biomarker subtype: gene

Clinical application: prognosis(unfavorable)

Histology type: endometrioid endometrial carcinoma

Stage: stage I

Country: Norway

Region: Stavanger

Followed up time : 66 months (1-209),

Protocol age: 66;37–94

Sample type : tissue

Clinical method: immunohistochemical /tissue microarrays,image cytometry/PCR

Expression pattern : low p21(<1%) , high survivin expression(>158) and high microsatellite instability

Expression elevation: Due to the specific staining pattern of survivin (scattered positive cell), the number of positive nuclei per 1.11 mm2 (ie the surface area of one tissue microarray cylinder at specimen level, after correction for irregular cylinder boundaries) was used as the ‘Survivin Index.’

Statictics: Median;Range

Protocol age: 66;37–94

Description: We conclude that low p21 and high survivin expression are poor prognosis indicators in FIGO stage I endometrial endometrioid adenocarcinoma, especially when high microsatellite instability occurs.

Approved symbol: BIRC5

Approved name: baculoviral IAP repeat containing 5

Locus type: gene with protein product

HGNC ID: HGNC:593

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:593

Symbol status: Approved

Previous symbols: API4

Alias symbols: EPR-1 survivin

Alternative gene group name: inhibitor of apoptosis domain containing", "IAP repeat containing", "Baculovirus inhibitor of apoptosis protein repeat containing"$"CPC"

OMIM: 603352

Omim link: https://www.omim.org/entry/603352

NCBI name: 332

NCBI link: https://www.ncbi.nlm.nih.gov/gene/332

Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Expression: Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/332#gene-expression

PDB ID: O15392

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(O15392)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

CC term ID: GO:1990713

CC term name: survivin complex

Source description: CORUM

Term ID: CORUM:2580$CORUM:1117

Term name: Survivin homodimer complex$CRM1-Survivin mitotic complex